{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T22:30:33Z","timestamp":1725057033846},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T00:00:00Z","timestamp":1156377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>The present case involves unique enteritis forming multiple ulcers associated with Epstein\u2013Barr virus (EBV). A 57\u2010year\u2010old man had undergone a reduced intensity allogeneic stem cell transplantation for a relapse of multiple myeloma following sequential autologous peripheral blood stem cell transplantation. The ileum, resected for massive melena, showed multiple irregular ulcers with occasional cobblestone\u2010like appearance. There was inflammation including numerous plasma cells in the ulcer bases and surrounding areas, where many EBV\u2010infected plasma cells were detected by double staining with EBV\u2010encoded small RNA\u20101 (EBER\u20101) <jats:italic>in situ<\/jats:italic> hybridization and CD79a, while EBV\u2010infected epithelial cells were not noted. The number of EBER\u20101\u2010positive cells in the ileum (mucosa, 1451\u2003cells\/mm<jats:sup>2<\/jats:sup>; submucosa, 465\u2003cells\/mm<jats:sup>2<\/jats:sup>) was much larger than in control samples (malignant lymphoma or leukemia after allogeneic stem cell transplantation, <jats:italic>n<\/jats:italic>\u2003=\u20034, range 0\u2013113\u2003cells\/mm<jats:sup>2<\/jats:sup>; malignant lymphoma after chemotherapy, <jats:italic>n<\/jats:italic>\u2003=\u200314, range 0\u20130.89\u2003cells\/mm<jats:sup>2<\/jats:sup>; colon cancer, <jats:italic>n<\/jats:italic>\u2003=\u200312, range 0\u20133.5\u2003cells\/mm<jats:sup>2<\/jats:sup>). In the mucosa near the ulcers, EBER\u20101\u2010positive cells often surrounded and involved the glandular epithelium, forming lymphoepithelial\u2010like lesions. The histological findings differ from post\u2010transplant lymphoproliferative disorders or intestinal thrombotic microangiopathy, and this is the first case of EBV\u2010associated enteritis with ulcers characterized by numerous plasma cells and lymphoepithelial\u2010like lesions after stem cell transplantation.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.02001.x","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T22:29:29Z","timestamp":1156890569000},"page":"530-537","source":"Crossref","is-referenced-by-count":18,"title":["Epstein\u2013Barr virus\u2010associated enteritis with multiple ulcers after stem cell transplantation: First histologically confirmed case"],"prefix":"10.1111","volume":"56","author":[{"given":"Yukie","family":"Tashiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Shirahama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atae","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Eizuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Yonezawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2002.1.392"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg317"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.11.4383.4383"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1182\/blood.V83.7.1980.1980","article-title":"Effect of T\u2010cell depletion as graft\u2010versus\u2010host disease prophylaxis on engraftment, relapse, and disease\u2010free survival in unrelated marrow transplantation for chronic myelogenous leukemia","volume":"83","author":"Drobyski WR","year":"1994","journal-title":"Blood"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.12.4357"},{"key":"e_1_2_7_7_2","first-page":"94","article-title":"Fatal herpesvirus\u20106 encephalitis in a recipient of a T\u2010cell\u2010depleted peripheral blood stem cell transplant from a 3\u2010loci mismatched related donor","volume":"85","author":"Tiacci E","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00282.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701359"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704513"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704512"},{"key":"e_1_2_7_12_2","first-page":"428","article-title":"Biopsy diagnosis of the ischemic enterocolitis associated with thrombotic microangiopathy","volume":"41","author":"Hirabayashi N","year":"2000","journal-title":"Ketsueki Shuyouka"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.1.55.401k04_55_65"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0131"},{"key":"e_1_2_7_15_2","first-page":"825","article-title":"1994 Consensus Conference on Acute GVHD Grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1993.tb03078.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.2.377.377"},{"key":"e_1_2_7_18_2","first-page":"2208","article-title":"Risk of lymphoproliferative disorders after bone marrow transplantation: A multi\u2010institutional study","volume":"94","author":"Curtis RE","year":"1999","journal-title":"Blood"},{"key":"e_1_2_7_19_2","first-page":"264","volume-title":"World Health Organization Classification of Tumours. 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