{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:13:22Z","timestamp":1776460402706,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T00:00:00Z","timestamp":1156377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>Described herein is a rare case of intraosseous melanotic schwannoma (MS) occurring in a long bone of a 13\u2010year\u2010old girl with a loss of heterozygosity (LOH) at 17q22\u201024, which contains the <jats:italic>PRKAR1A<\/jats:italic> gene encoding the protein kinase A regulatory subunit 1\u2010<jats:italic>a<\/jats:italic>. Plain radiography and magnetic resonance imaging revealed a 10\u2003cm expansile osteolytic lesion involving the proximal fibula. An excisional biopsy revealed a cellular tumor consisting of mildly pleomorphic spindle or oval to polygonal cells with frequent intranuclear pseudoinclusions, intracytoplasmic melanin pigments, nuclear palisades, Verocay body\u2010like structures, and psammomatous calcifications. The tumor cells showed strong immunoreactivity for S\u2010100 protein, HMB\u201045, and neuron\u2010specific enolase. Ultrastructurally, the tumor cells were invested by continuous, multiplied external lamina and conspicuous melanosomes in various stages of maturation. These observations were compatible with psammomatous melanotic schwannoma (PMS). In addition, the detection of LOH for <jats:italic>PRKAR1A<\/jats:italic> strongly suggests that PMS in the present case is a manifestation of the Carney complex (CNC).<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.02002.x","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T22:29:29Z","timestamp":1156890569000},"page":"538-542","source":"Crossref","is-referenced-by-count":19,"title":["Primary intraosseous melanotic schwannoma of the fibula associated with the Carney complex"],"prefix":"10.1111","volume":"56","author":[{"given":"Mi\u2010Jung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jene","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Kwang","family":"Khang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Ja","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199003000-00002"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880701)62:1<174::AID-CNCR2820620127>3.0.CO;2-G"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/79238"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.20.3037"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-004-2744-2"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0022-5223(19)41219-1","article-title":"Melanotic malignant schwannoma of the right atrium","volume":"74","author":"Gelfand ET","year":"1977","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.12.1449"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700820203"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/93.3.424"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700350305"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-7192(03)00006-4"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.4.484"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01280.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198402000-00007"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200403000-00010"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00001"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00786.x"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2006.02002.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2006.02002.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T10:04:31Z","timestamp":1697277871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2006.02002.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,24]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1440-1827.2006.02002.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2006.02002.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,24]]}}}