{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:15:40Z","timestamp":1767849340118,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T00:00:00Z","timestamp":1156377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>A 7\u2010year\u2010old girl was hospitalized because of a tumorous mass in her left periorbital region. The tumor was removed by local excision. The soft\u2010part tumor recurred in the parotid gland region 4\u2003months later, and a second recurrence was noted on the left side of the neck 3\u2003years and 3\u2003months thereafter. The patient had not received chemotherapy or local irradiation. Histological and immunohistochemical examinations of the recurrent masses revealed morphological characteristics of small cell proliferation with desmoplastic stroma that were similar to those of the initial tumor. The cellular components showed immunoreactivity for desmin, cytokeratin, vimentin, and epithelial membrane antigen in part, but the cells were negative for myogenin, CD99, and neuron\u2010specific enolase. These findings suggested a diagnosis of desmoplastic small cell tumor, despite its extra\u2010abdominal location. The histological diagnosis was confirmed by reverse transcriptase polymerase chain reaction, which demonstrated an <jats:italic>EWS\u2010WT1<\/jats:italic> chimeric fusion gene. An in\u2010frame fusion of <jats:italic>EWS<\/jats:italic> exon 9 and <jats:italic>WT1<\/jats:italic> exon 8 was subsequently identified by cloning and sequencing. The chimeric fusion gene might be related to the tissue\u2010specific phenotype of desmoplastic small cell tumors, although further investigation of this speculation is necessary.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.02003.x","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T22:29:29Z","timestamp":1156890569000},"page":"543-548","source":"Crossref","is-referenced-by-count":13,"title":["Desmoplastic small cell tumor of soft tissue: Molecular variant of <i>EWS<\/i>\u2010<i>WT1<\/i> chimeric fusion"],"prefix":"10.1111","volume":"56","author":[{"given":"Minoru","family":"Hamazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Okita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010ichi","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taemi","family":"Nara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,24]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"9","article-title":"Polyphenotypic small cell tumors of childhood [Abstract]","volume":"58","author":"Swanson PE","year":"1988","journal-title":"Lab Invest"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5752"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/359162a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1998.tb03274.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408043310503"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199911000-00012"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199106000-00001"},{"key":"e_1_2_6_9_2","first-page":"2837","article-title":"Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor","volume":"54","author":"Ladanyi M","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199608000-00011"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199808000-00014"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.5858\/1999-123-1246-MPOSTA","article-title":"Molecular pathology of soft tissue and bone tumors","volume":"123","author":"Slominski A","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126782.94781.dc"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90094-J"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513819509027015"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199702000-00013"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199506000-00006"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199601000-00013"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199703000-00017"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199802000-00005"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.9.3028"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200208000-00001"},{"key":"e_1_2_6_23_2","first-page":"1584","article-title":"Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction. 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