{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T06:10:49Z","timestamp":1697004649845},"reference-count":8,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>Gynecomastia is a benign proliferative lesion caused by various etiological factors and may result from a relative imbalance between serum estrogen and androgen levels. The histological alterations are similar, and gynecomastia can progress from a florid type to a fibrous type. The Ki\u201067 labeling index (LI) of gynecomastia specimen was investigated and higher Ki\u201067 LI was observed in florid and intermediate than in fibrous gynecomastia (<jats:italic>P<\/jats:italic>\u2003=\u20030.017). A correlation was found between the duration of disease and Ki\u201067 LI (<jats:italic>P<\/jats:italic>\u2003=\u20030.041): the shorter the duration the higher the Ki\u201067 LI. Thus, Ki\u201067 LI seems a useful tool to examine proliferation activity of gynecomastia and can assist in determination of appropriate treatment of gynecomastia with hormonal therapy.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.02025.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T06:12:23Z","timestamp":1161151943000},"page":"655-658","source":"Crossref","is-referenced-by-count":8,"title":["Immunohistochemical study of the relationship between Ki\u201067 labeling index of proliferating cells of gynecomastia, histological phase and duration of disease"],"prefix":"10.1111","volume":"56","author":[{"given":"Seishi","family":"Kono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kurosumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanako","family":"Simooka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kawanowa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimito","family":"Suemasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/57.4.431"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302183280708"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(63)90044-5"},{"key":"e_1_2_5_5_2","first-page":"3283","article-title":"Analysis of correlation between mitotic index, MIB1 score and S\u2010phase fraction as proliferation markers in invasive breast carcinoma. 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