{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:55:41Z","timestamp":1760244941996},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T00:00:00Z","timestamp":1170374400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>Extranodal marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue type (MALT lymphoma) usually lacks CD5 expression. Herein is described two cases of CD5\u2010positive MALT lymphoma of ocular adnexal origin. The differential diagnosis between CD5\u2010positive MALT lymphoma and mantle cell lymphoma (MCL), notably cyclin D1\u2010negative MCL, was difficult because both cases consisted histologically of small to medium\u2010sized cells with diffuse or vaguely nodular growth pattern, and the neoplastic cells were positive for CD5 and negative for cyclin D1. Somatic mutation analysis of the <jats:italic>immunoglobulin heavy chain variable region (VH)<\/jats:italic> gene in case 1 found a relatively higher mutation frequency (5.0%), which was not definitive to rule out MCL. Interphase fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) on paraffin\u2010embedded section using IgH\/cyclin D1 (CCND1) probe showed that in both cases there was no molecular evidence of t(11;14), finally leading to the diagnosis of CD5\u2010positive MALT lymphoma. Although the present two patients had no recurrence over 34\u2003months after initial diagnosis, careful observation is needed because the clinicopathological significance of MALT lymphoma with this rare phenotype remains obscure.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.02063.x","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T07:41:21Z","timestamp":1170488481000},"page":"101-107","source":"Crossref","is-referenced-by-count":20,"title":["CD5\u2010positive mucosa\u2010associated lymphoid tissue (MALT) lymphoma of ocular adnexal origin: Usefulness of fluorescence <i>in situ<\/i> hybridization for distinction between mantle cell lymphoma and MALT lymphoma"],"prefix":"10.1111","volume":"57","author":[{"given":"Kazuhiro","family":"Tasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Shichishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,2]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"157","volume-title":"WHO Classification. 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