{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:45:20Z","timestamp":1774449920251,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T00:00:00Z","timestamp":1170374400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>Primary gastric lymphoma usually originates from B cells of mucosa\u2010associated lymphoid tissue (MALT) infected with <jats:italic>Helicobacter pylori.<\/jats:italic> When T\u2010cell lymphomas develop in the stomach, they usually occur in association with infection by human T\u2010lymphotropic virus type 1 and gastric involvement of adult T\u2010cell leukemia. Reported herein is a unique and informative case of gastric peripheral T\u2010cell lymphoma with a cytotoxic phenotype that histologically mimicked, and had to be carefully distinguished from, MALT\u2010type B\u2010cell lymphoma. The patient, a 73\u2010year\u2010old woman, underwent a gastric endoscopy examination, and the histological findings suggested MALT\u2010type gastric lymphoma. Analysis of the <jats:italic>immunoglobulin heavy chain (IgH)<\/jats:italic> gene and <jats:italic>T cell receptor \u03b3 (TCR\u03b3)<\/jats:italic> gene revealed monoclonal rearrangement of the TCR\u03b3 gene. The tumor cells exhibited mild atypia and immunoreactivity with anti\u2010CD3, anti\u2010CD8, anti\u2010T\u2010cell intracellular antigen\u20101, antigranzyme B and antiperforin antibodies, but not with anti\u2010CD20, anti\u2010CD10, and anti\u2010CD79a antibodies. The case was finally diagnosed as gastric T\u2010cell lymphoma with cytotoxic phenotype, and this was confirmed after surgical resection. In cases such as this, small biopsy specimens from the stomach should be examined carefully for low grade B\u2010cell\u2010type malignant lymphoma (MALT lymphoma), because sometimes the proliferating B cells can hide the truly malignant T cells, and rearrangement analysis is useful for diagnosing T\u2010cell malignancy.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.02065.x","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T07:41:21Z","timestamp":1170488481000},"page":"108-114","source":"Crossref","is-referenced-by-count":12,"title":["Gastric T\u2010cell lymphoma with cytotoxic phenotype"],"prefix":"10.1111","volume":"57","author":[{"given":"Shintaro","family":"Sugita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichiro","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Kano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Yanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,2]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"World Health Organization Classification of Tumours, Pathology and Genetics of Tumors of the Digestive System.","author":"Hamilton SR","year":"2000"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90060-4"},{"key":"e_1_2_5_4_2","first-page":"151","article-title":"Gastrointestinal lymphomas of T\u2010 and B\u2010cell types","volume":"2","author":"Issacson PG","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01657.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00277-003-0612-6","article-title":"Primary gastric T\u2010cell lymphoma not associated with human T\u2010lymphotrophic virus type 1: A case report and review of the literature","volume":"82","author":"Niitsu N","year":"2003","journal-title":"Ann Hematol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2000.01118.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009053543"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90060-I"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050459"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00566.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01459.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.2.269"},{"key":"e_1_2_5_14_2","first-page":"504","article-title":"Aggressive gastric peripheral T\u2010cell lymphoma of CD8+ type associated with lymphomatous meningitis","volume":"10","author":"Holst VA","year":"1997","journal-title":"Mod Pathol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/29.3.171"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970715)80:2<292::AID-CNCR18>3.0.CO;2-P"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005950200091"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200206000-00002"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199506000-00006"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200009000-00002"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199503000-00005"},{"key":"e_1_2_5_22_2","first-page":"1297","article-title":"HML\u20101 antigen on mucosa\u2010associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the \u03b27 subunit","volume":"139","author":"Micklem KJ","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170910"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.011734"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880229"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880265"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880133"},{"key":"e_1_2_5_28_2","volume-title":"World Health Organization Classification of Tumours, Tumors of Haematopoietic and Lymphoid Tissue.","author":"Jaffe ES","year":"2001"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2006.02065.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2006.02065.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T15:30:08Z","timestamp":1696951808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2006.02065.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1440-1827.2006.02065.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2006.02065.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}