{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:13:23Z","timestamp":1774970003791,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T00:00:00Z","timestamp":1170979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>Soft\u2010tissue sarcomas or malignant soft\u2010tissue tumors are malignant tumors arising from soft tissues of mesenchymal origin. These soft\u2010tissue tumors can develop from any site in the body, including the extremities, trunk, retroperitoneum, or the head\/neck region. In Japan, soft\u2010tissue sarcomas are rarely encountered, with an incidence of approximately 2 per 100\u2003000 population. Diverse types (more than 30 types) of soft\u2010tissue sarcomas are known. Pathological examination of biopsy or resected specimens is indispensable for a definitive diagnosis of soft\u2010tissue sarcomas. Needless to say, early detection and treatment based on accurate diagnosis are the basic principles of the management of soft\u2010tissue sarcomas. The purpose of the present paper was to address the histological grading of soft\u2010tissue sarcomas (the most important histopathological prognostic factor for this type of sarcoma) based on the French F\u00e9d\u00e9ration Nationale des Centres de Lutte Contre Ie Cancer (FNCLCC) system, the histological grading of this type of sarcoma based on the MIB\u20101 labeling index (an immunohistochemical marker of cell proliferation; MIB\u20101 system), precautions that must be taken while evaluating the degree of malignancy and the relationship of the grade with other clinicopathological factors.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.02068.x","type":"journal-article","created":{"date-parts":[[2007,2,10]],"date-time":"2007-02-10T10:04:38Z","timestamp":1171101878000},"page":"121-125","source":"Crossref","is-referenced-by-count":26,"title":["Histological grading and MIB\u20101 labeling index of soft\u2010tissue sarcomas"],"prefix":"10.1111","volume":"57","author":[{"given":"Tadashi","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,9]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"12","volume-title":"World Health Organization Classification of Tumours. 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