{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:55:41Z","timestamp":1760244941261},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T00:00:00Z","timestamp":1170979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>Bcl2 is an important protein involved in the pathogenesis of follicular lymphoma (FL). However, approximately 10% of FL cases do not express Bcl2. The present study was designed to compare gene aberrations, prosurvival gene expression, apoptosis and proliferation rates in Bcl2\u2010positive and \u2010negative FL cases. <jats:italic>Bcl2<\/jats:italic> translocation and <jats:italic>Bcl6<\/jats:italic> translocation were detected and compared using fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH). A tendency for <jats:italic>Bcl6<\/jats:italic> translocation to occur was found more frequently in Bcl2\u2010negative FL than in the Bcl2\u2010positive cases. The expression of Bcl\u2010X, BAX, p53, Bcl6 was analyzed by immunohistochemistry. Bcl2 family proteins Bcl\u2010X and BAX were expressed similarly in the two FL types. In some cases of Bcl2\u2010negative FL there was high expression of Bcl6 or p53 but no such Bcl2\u2010positive FL cases were detected. Furthermore, there was an inverse relationship between the expression of Bcl6 and p53. These results indicate that the <jats:italic>Bcl6<\/jats:italic> translocation occurs more frequently in Bcl2\u2010negative FL. Furthermore, other prosurvival proteins such as p53 and Bcl6 may play an important role in the pathogenesis of Bcl2\u2010negative FL.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.02072.x","type":"journal-article","created":{"date-parts":[[2007,2,10]],"date-time":"2007-02-10T10:04:38Z","timestamp":1171101878000},"page":"148-152","source":"Crossref","is-referenced-by-count":23,"title":["Bcl2\u2010negative follicular lymphomas frequently have <i>Bcl6<\/i> translocation and\/or Bcl6 or p53 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