{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:41:33Z","timestamp":1789940493862,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:00:00Z","timestamp":1172102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm that is benign in most cases. Although SFT was first recognized to arise only in the pleura, recent reports indicate that SFT can involve a wide range of anatomical sites. To date, 17 cases of pelvic SFT have been reported. Herein is reported a case of a 74\u2010year\u2010old woman with a giant malignant SFT in the pelvis. Along with massive invasion to adjacent organs and multiple lung metastases detected on radiography, biopsy from the tumor through the vaginal wall showed malignant looking spindle\u2010cell neoplasm with increased cellularity, areas of necrosis, and high mitotic activity (5\/10\u2003high\u2010power fields). Immunohistochemically, the tumor cells were diffusely and strongly positive for CD34, CD99, and bcl\u20102. Based on pathological features and clinical presentation, diagnosis of malignant SFT was made. The patient received systemic and the intra\u2010arterial chemotherapy followed by whole pelvic radiation therapy (50\u2003Gy). Initial chemotherapies failed to control the tumor. Afterwards, improvement was observed radiologically and pathologically in the 12\u2003months' follow up after the radiation therapy. This is the first report related to therapeutic remarks on advanced malignant SFT.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2007.02083.x","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T10:43:25Z","timestamp":1172141005000},"page":"213-218","source":"Crossref","is-referenced-by-count":57,"title":["Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy"],"prefix":"10.1111","volume":"57","author":[{"given":"Shinobu","family":"Kawamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Oya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Ishizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810601)47:11<2678::AID-CNCR2820471126>3.0.CO;2-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.233025165"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.07.013"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.2400897.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10328"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199807000-00008"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199812000-00007"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00412.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.11.009"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198908000-00003"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041866"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.079"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850801)56:3<475::AID-CNCR2820560311>3.0.CO;2-S"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.197"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199704)181:4<362::AID-PATH764>3.0.CO;2-Y"},{"key":"e_1_2_6_17_2","first-page":"443","article-title":"Extrapleural solitary fibrous tumor: A report of seven cases","volume":"10","author":"Fukunaga M","year":"1997","journal-title":"Mod Pathol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90169-7"},{"key":"e_1_2_6_19_2","first-page":"1034","article-title":"Extrapleural solitary fibrous tumor: A clinicopathologic study of 24 cases","volume":"12","author":"Brunnemann RB","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_6_20_2","first-page":"675","article-title":"Solitary fibrous tumor: The clinicopathologic and immunohistochemical characteristics of 26 cases","volume":"35","author":"Chen HJ","year":"2004","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_6_21_2","first-page":"86","volume-title":"World Health Organization Classification of Tumours. 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