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At the same time, GC have been known to be a major source of B\u2010cell lymphomas including follicular and Burkitt's, and also some diffuse large B\u2010cell lymphomas. Therefore, uncovering the biological characteristics of GC would greatly contribute to understanding lymphomagenesis, or progression of B\u2010cell lymphomas of GC origin. Herein the authors briefly explain the expression and pathophysiological significance of apoptosis regulators in GC, focusing particularly on Bcl\u20102, Fas (CD95) and a transcription factor, nuclear factor of activated T\u2003cells, which seems to play a critical role in regulating cellular dynamics of GC B\u2003cells via B\u2010cell antigen receptor. The expression of these molecules is then compared with that of the neoplastic counterpart B\u2010cell lymphomas in order to consider lymphomagenesis of GC origin. In conclusion, follicular lymphoma closely reflected characteristics of GC among these B\u2010cell lymphomas, although it acquires strong expression of apoptosis\u2010resistant gene, <jats:italic>bcl\u20102<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2007.02115.x","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T17:02:05Z","timestamp":1182445325000},"page":"391-397","source":"Crossref","is-referenced-by-count":17,"title":["Expression of apoptosis regulators in germinal centers and germinal center\u2010derived B\u2010cell lymphomas: Insight into B\u2010cell 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