{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T06:10:50Z","timestamp":1697004650528},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T00:00:00Z","timestamp":1182384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>Mutations in <jats:italic>p53<\/jats:italic> gene exons 5\u20139 were studied in 44 non\u2010Hodgkin's lymphomas (NHL) consisting of 35 B\u2010NHL and 9 T\u2010NHL. Missense mutations were found in two diffuse large B\u2010cell lymphomas (DLBL) and one peripheral T\u2010cell lymphoma (unspecified). Double transversion missense and nonsense mutations were detected in one DLBL and one adult T\u2010cell leukemia\/lymphoma. Silent mutations were found in two DLBL. Detailed histomorphological study showed that cases harboring <jats:italic>p53<\/jats:italic> missense mutation with\/without nonsense mutation tended to have larger nuclei with much more prominent nucleoli. Cytomorphometric analysis was therefore conducted by measuring the gross area of 100 lymphoma cell nuclei in 44 cases and the results were compared between lymphomas harboring <jats:italic>p53<\/jats:italic> missense mutation with\/without nonsense mutation and lymphomas harboring <jats:italic>p53<\/jats:italic> silent mutation or lacking mutation. It was found that the lymphomas harboring <jats:italic>p53<\/jats:italic> missense mutation with\/without nonsense mutation had a highly significantly larger nuclear gross area than lymphomas with silent <jats:italic>p53<\/jats:italic> mutation or lacking mutation (two\u2010sample <jats:italic>t<\/jats:italic>\u2010test, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.00001; Exact Wilcoxon rank\u2013sum test, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.00001). This result suggests that <jats:italic>p53<\/jats:italic> mutation might induce enlargement of neoplastic cell nuclei by some molecular mechanism.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2007.02119.x","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T17:02:05Z","timestamp":1182445325000},"page":"430-436","source":"Crossref","is-referenced-by-count":2,"title":["Missense mutation with\/without nonsense mutation of the <i>p53 <\/i>gene is associated with large cell morphology in human malignant lymphoma"],"prefix":"10.1111","volume":"57","author":[{"given":"Shoko","family":"Mitani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsunori","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Tango","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigero","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60785-X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81871-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2683079"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.6.5.1379"},{"key":"e_1_2_6_6_2","first-page":"4855","article-title":"Mutations 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