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Tumor regression by <jats:italic>H.\u2003pylori<\/jats:italic> eradication alone is well known in gastric MALT lymphoma, but some tumors occur in the absence of pre\u2010existing chronic inflammation. The understanding of MALT lymphoma biology has significantly improved, and recurrent cytogenetic alterations have been detected. These include the trisomies 3 and 18, and the translocations t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21), and t(3;14)(p14.1;q32). At least some of these alterations result in the constitutive activation of the nuclear factor (NF)\u2010\u03baB pathway, and may exert anti\u2010apoptotic action. <jats:italic>Apoptosis inhibitor 2\u2013MALT lymphoma\u2010associated translocation 1<\/jats:italic> (<jats:italic>API12<\/jats:italic>\u2010<jats:italic>MALT1<\/jats:italic>) fusion, resulting from t(11;18)(q21;q21), is specific to, and is the most common in, MALT lymphomas, and its clinicopathological significance has been studied extensively. The focus of the present review is on the recent progress made in elucidating MALT lymphomagenesis and its clinicopathological impact, especially in terms of the effect of <jats:italic>API2\u2010MALT1<\/jats:italic> fusion on this unique tumor.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2007.02128.x","type":"journal-article","created":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T04:42:30Z","timestamp":1183351350000},"page":"474-484","source":"Crossref","is-referenced-by-count":55,"title":["Mucosa\u2010associated lymphoid tissue lymphoma: Molecular pathogenesis and clinicopathological significance"],"prefix":"10.1111","volume":"57","author":[{"given":"Hiroshi","family":"Inagaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_6_3_2","first-page":"157","volume-title":"World Health Organization Classification of Tumours. 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