{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:25:53Z","timestamp":1768818353272,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T00:00:00Z","timestamp":1196899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>Amiodarone is well recognized as an anti\u2010arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction. The present patient was a 66\u2010year\u2010old Japanese woman who developed a cardiac arrhythmia and was given amiodarone as an anti\u2010arrhythmic agent for approximately 3\u2003months, until the day before her death. However, 19\u2003days after starting amiodarone, serum testing indicated a hypothyroid status that was not recognized clinically. At autopsy, microscopy showed that most of the thyroid follicles were enlarged with dense colloid substance and lined by flattened follicular cells (involuted follicles). There were a small number of damaged follicles infiltrated by macrophages, which were immunopositive for HAM56. Sudan IV staining indicated many lipid droplets in follicular cells. Ultrastructurally the follicular cells contained large residual bodies composed of abundant electron\u2010lucent lipid droplets of variable size. Although it is difficult to be certain of the direct link of amiodarone on the basis of a single case, it is reasonable to presume that this histopathology is associated with amiodarone\u2010induced hypothyroidism and that involution changes represent the hypofunctional status of this drug\u2010induced disorder. This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone\u2010induced hypothyroidism.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2007.02189.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T12:33:02Z","timestamp":1281616382000},"page":"55-58","source":"Crossref","is-referenced-by-count":17,"title":["Histopathology of the thyroid in amiodarone\u2010induced hypothyroidism"],"prefix":"10.1111","volume":"58","author":[{"given":"Tadao","family":"Nakazawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Yamane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Iwasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Katoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003303421302"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.19.2025"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90187-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198703000-00004"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1400241"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1994.tb01679.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03349834"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.5858\/2004-128-807-ATATCC","article-title":"Amiodarone\u2010induced thyrotoxicosis and thyroid cancer","volume":"128","author":"Saad A","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.5858\/2003-127-e275-PQCAYO","article-title":"Pathologic quiz case. A 66\u2010year old man with thyrotoxicosis","volume":"127","author":"Carlsten JR","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.2000.01780.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(86)90192-X"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00224420"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2007.02189.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2007.02189.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:18:19Z","timestamp":1696889899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2007.02189.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,6]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1111\/j.1440-1827.2007.02189.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2007.02189.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,6]]}}}