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To elucidate the clinicopathological characteristics of AIP\u2010associated prostatitis (AIP\u2010P), the clinicopathological findings of AIP\u2010P patients were evaluated, and the immunohistochemical expression of the IgG subclasses (IgG1, IgG2, IgG3, and IgG4) in six AIP\u2010P patients was compared with that in 10 control patients who were clinically diagnosed as suspicious for carcinoma but who had focal inflammation without adenocarcinoma on histological examination of the prostate. All AIP\u2010P patients had the characteristic findings of AIP, and their lower urinary tract symptoms (LUTS) improved after steroid therapy. In four of five AIP\u2010P patients, digital rectal examination indicated prostate enlargement. Histologically, AIP\u2010P had lymphoplasmacytic and scattered eosinophilic infiltration and obliterative phlebitis accompanying gland atrophy with dense fibrosis. Immunohistochemically, the IgG4\u2010positive plasma cell\/mononuclear cell ratio was significantly higher in the AIP\u2010P group than in the control group (<jats:italic>P<\/jats:italic>\u2003= 0.0011). AIP\u2010P is a distinct clinicopathological entity, and a mechanism similar to that implicated in AIP may be involved in it as well.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2007.02199.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T12:20:20Z","timestamp":1281615620000},"page":"118-125","source":"Crossref","is-referenced-by-count":82,"title":["Autoimmune pancreatitis\u2010associated prostatitis: Distinct clinicopathological entity"],"prefix":"10.1111","volume":"58","author":[{"given":"Takeshi","family":"Uehara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Kawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Oki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"e_1_2_6_3_2","first-page":"2607","article-title":"Autoimmune chronic pancreatitis simulating pancreatic lymphoma","volume":"91","author":"Horiuchi A","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00260.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018862626221"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90087-6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF02785924","article-title":"Sclerosing pancreatitis showing rapidly progressive changes with recurrent mass formation","volume":"21","author":"Motoo Y","year":"1997","journal-title":"Int J Pancreatol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02232341"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.6.6.545"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026621913192"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02285209"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00603-0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.058438"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.02.044"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.09.011"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.5858\/2005-129-1148-APMTJA","article-title":"Autoimmune pancreatitis: More than just a pancreatic disease? 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