{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:10:32Z","timestamp":1780103432115,"version":"3.54.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T00:00:00Z","timestamp":1215648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>In endometrioid adenocarcinoma of the uterine corpus, nodal metastasis is related to prognosis. D2\u201040 immunostaining has recently been used to detect lymphatic invasion, but a study of D2\u201040 immunostaining for endometrioid adenocarcinoma of the uterine corpus has not been published. Therefore, as a predictor of nodal metastasis in endometrioid adenocarcinoma of the uterine corpus, the detection of lymphatic invasion on D2\u201040 immunostaining and lymphovascular invasion on HE stain was compared. A total of 104 cases of invasive endometrioid adenocarcinoma of the uterine corpus, in which the tumor was located in the uterus, were examined on immunohistochemistry using D2\u201040. In 20 cases there was lymphatic invasion according to D2\u201040 immunostaining, and the lymphatic invasion was well detected on D2\u201040 immunostaining. Nodal metastasis was present in 11 cases. Both lymphatic invasion on D2\u201040 immunostaining and lymphovascular invasion on HE stain were statistically correlated with nodal metastasis, but the evaluation of lymphatic invasion on D2\u201040 immunostaining was more accurate than detection of lymphovascular invasion using HE stain, in the current and previous studies, for the prediction of nodal metastasis. In conclusion, lymphatic invasion demonstrated on D2\u201040 immunostaining is very useful as a predictor for nodal metastasis in endometrioid adenocarcinoma of uterine corpus.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2008.02258.x","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T14:34:46Z","timestamp":1215614086000},"page":"471-476","source":"Crossref","is-referenced-by-count":9,"title":["Lymphatic invasion according to D2\u201040 immunostaining is a predictor of nodal metastasis in endometrioid adenocarcinoma of the uterine corpus"],"prefix":"10.1111","volume":"58","author":[{"given":"Yasuka","family":"Miyakuni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sonoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,10]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"153","article-title":"Endometrial carcinoma. 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