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Histology of the following core needle biopsy (CNB) specimen indicated diffuse large B\u2010cell lymphoma (DLBCL). The patient had no past history of lymphoma and there was no evidence of systemic lymph nodes enlargement. After CNB, however, the patient noticed that her breast nodule gradually decreased in size without any specific treatment. Subsequent MRI showed an ill\u2010defined nodular area suggesting a regressing tumor. Excisional biopsy indicated fibrotic mammary tissue devoid of large neoplastic lymphoid cells. The patient has remained well without evidence of recurrent lymphoma more than 18\u2003months after her original diagnosis. This case is considered to be unique in a PBL showing SR, probably induced by an intervention of CNB and histologically confirmed on sequential examinations in addition to illustrative before\u2010and\u2010after imaging. To the best of the authors' knowledge no other PBL of DLBCL has been reported as undergoing a complete SR in the English\u2010language literature.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2009.02424.x","type":"journal-article","created":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T09:12:44Z","timestamp":1250154764000},"page":"664-669","source":"Crossref","is-referenced-by-count":10,"title":["Spontaneous regression of primary breast 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