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The aim of the present study was to evaluate the status of endothelial cells using CD105 and Ki\u201067 immunohistochemistry in benign and malignant lesions of the uterine cervix. Double stain for CD105\/Ki\u201067 in benign and malignant lesions of the uterine cervix showed that these two markers had divergent expression on endothelial cells from associated tumor blood vessels dependent on lesion type and proliferation status of tumor cells. Absence of CD105\/Ki\u201067 coexpression in endothelial cells was correlated with histopathology of the uterine cervix lesions and tumor proliferative status. The present findings suggest that CD105 expression is an early event, specific for premalignant lesions of the uterine cervix, while endothelial proliferation assessed on Ki\u201067 combined with the lack of CD105 expression is often associated with invasive cervical carcinoma.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2009.02431.x","type":"journal-article","created":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T06:33:42Z","timestamp":1253774022000},"page":"695-700","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of endoglin and Ki\u201067 expression in endothelial cells from benign and malignant lesions of the uterine cervix"],"prefix":"10.1111","volume":"59","author":[{"given":"Anca 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