{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:38:33Z","timestamp":1792633113732,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T00:00:00Z","timestamp":1260489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p> <jats:italic>Scedosporium prolificans<\/jats:italic> has been increasingly recognized as an etiological agent of disseminated mycelial infections in profoundly immunocompromised patients. Reported herein is a case of disseminated <jats:italic>S.\u2003prolificans<\/jats:italic> infection in a patient undergoing anti\u2010neoplastic chemotherapy for acute myeloid leukemia. Antemortem blood culture yielded <jats:italic>S.\u2003prolificans<\/jats:italic>, which was confirmed on conventional morphological examination and polymerase chain reaction\u2010based DNA sequencing targeting internally transcribed spacer regions. Histopathology of autopsy specimens indicated fungal infection in the heart, lungs, liver, kidneys, spleen, pancreas and gastrointestinal tract, with the development of hemorrhagic and ischemic necrosis. The infecting fungus had developing septate hyphae and was identified as belonging to the genus <jats:italic>Scedosporium<\/jats:italic>, on <jats:italic>in situ<\/jats:italic> hybridization of tissue. The combination of haphazardly branching hyphae and lemon\u2010shaped conidia appeared to be the most useful distinguishing features to allow differentiation of this fungus from other filamentous fungi in tissue. Three other unique histopathological characteristics of the fungus were noted: (i) parallel hyphae bridged at right angles to produce letter\u2010H patterns; (ii) intravascular conidiation; and (iii) purple conidia in tissue, though these are usually described as brown in most text books. Precise histopathology, in addition to other techniques such as <jats:italic>in situ<\/jats:italic> hybridization, can aid in the identification of etiological fungi.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2009.02491.x","type":"journal-article","created":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T09:02:22Z","timestamp":1260522142000},"page":"131-136","source":"Crossref","is-referenced-by-count":38,"title":["Unique histological characteristics of <i>Scedosporium<\/i> that could aid in its identification"],"prefix":"10.1111","volume":"60","author":[{"given":"Masatomo","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Maenishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyofumi","family":"Ohkusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,21]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"45","article-title":"Lomentospora prolificans, a new hyphomycete from greenhouse soil","volume":"1","author":"Hennebert GL","year":"1974","journal-title":"Mycotaxon"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.26.3.498-503.1988"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00436921"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.1.102"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/509579"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802524506"},{"key":"e_1_2_9_8_2","first-page":"678","volume-title":"Medical Mycology","author":"Kwon\u2010Chung KJ","year":"1992"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.8.2873-2879.2001"},{"key":"e_1_2_9_10_2","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi; Approved Standard","author":"CLSI","year":"2008"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200303000-00003"},{"key":"e_1_2_9_12_2","first-page":"1073","volume-title":"Pathology of Infectious Diseases","author":"Schwartz DA","year":"1997"},{"key":"e_1_2_9_13_2","first-page":"158","article-title":"Disseminated petriellidosis (allescheriosis)","volume":"102","author":"Walker DH","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_9_14_2","first-page":"619","article-title":"Pseudallescheria boydii in a patient with acute lymphoblastic leukemia","volume":"108","author":"Enggano IL","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972505"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00436855"},{"key":"e_1_2_9_17_2","first-page":"476","article-title":"Organ\u2010specific variation in the morphology of the fungomas (fungus balls) of Pseudallescheria boydii. 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