{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T09:12:13Z","timestamp":1698829933128},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,13]],"date-time":"2011-03-13T00:00:00Z","timestamp":1299974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>This report concerns a unique case of a composite lymphoma composed of T\u2010lymphoblastic leukemia\/lymphoma (T\u2010LBL) and diffuse large B\u2010cell lymphoma (DLBCL) in a 72\u2010year\u2010old woman with generalized lymphadenopathy, splenomegaly and ascites. Laboratory findings showed increased lactate dehydrogenase and soluble interleukin\u20102 receptor. The biopsy specimen showed replacement of the normal architecture of the lymph nodes by a tumor containing a dual cell population composed of large lymphocytes and medium\u2010sized lymphocytes. Sheets of large lymphocytes often were punctuated by clusters of medium\u2010sized lymphocytes. Flow cytometry and immunohistochemical analysis showed a composite lymphoma with both T\u2010LBL and DLBCL. The T\u2010LBL expressed CD1a, CD3, CD4, CD8, and terminal deoxynucleotidyl transferase. The DLBCL expressed CD19 and CD20, CD23, bcl\u20102, bcl\u20106, MUM1 and immunoglobulin \u03ba light chain. Polymerase chain reaction detected a monoclonal pattern of T\u2010cell receptor \u03b3 and immunoglobulin heavy chain rearrangements in the same specimen. She received eight cycles of R\u2010CHOP (rituximab+cyclophosphamide, doxorubicin, vincristine, prednisone) therapy and achieved complete remission. She has shown no signs of recurrence 20 months after the diagnosis. We describe here a very unusual and, to the best of our knowledge, an as yet never reported case of a primary composite lymphoma of T\u2010LBL and DLBCL.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2011.02662.x","type":"journal-article","created":{"date-parts":[[2011,3,14]],"date-time":"2011-03-14T01:30:35Z","timestamp":1300066235000},"page":"363-368","source":"Crossref","is-referenced-by-count":6,"title":["Composite T lymphoblastic leukemia\/lymphoma and diffuse large B\u2010cell lymphoma: Case report"],"prefix":"10.1111","volume":"61","author":[{"given":"Daisuke","family":"Niino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohsaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshizo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kiyasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,13]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"CusterR.Pitfalls in the diagnosis of lymphoma and leukemia from the pathologist's point of view. 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