{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:10:58Z","timestamp":1792145458140,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Peritoneal seeding (PS) of hepatocellular carcinoma (HCC) is uncommon, and the clinicopathological features are poorly understood. A total of 181 autopsy cases of HCC, including 171 cases with detailed clinical information, was investigated for PS and evaluated. PS was identified in 17 cases (9.4%), and was locally (70.6%) or entirely (29.4%) distributed in the peritoneal cavity, involving the diaphragm (76.5%), omentum (47.1%), or alimentary tract serosa (47.1%). Compared with primary HCC, PS showed similar or slightly undifferentiated features (88.2%) and exhibited more differentiated features (11.8%). In 15 cases (88.2%) of HCC with PS, primary HCC showed membranous \u03b2\u2010catenin immunoreactivity. However, in five cases (33.3%), respective PS lost this immunoreactivity. PS was significantly associated with rupture of HCC (<jats:italic>P<\/jats:italic>= 0.012), direct diaphragmatic invasion (<jats:italic>P<\/jats:italic>= 0.001), and lymph node metastasis (<jats:italic>P<\/jats:italic> &lt; 0.001), indicating these are high risk factors for PS; there was no significant association with a past history of percutaneous fine\u2010needle biopsy, percutaneous ethanol injection and\/or radiofrequency ablation (<jats:italic>P<\/jats:italic>= 0.97), or metastasis to lung (<jats:italic>P<\/jats:italic>= 0.13), bone (<jats:italic>P<\/jats:italic>= 0.71), or adrenal gland (<jats:italic>P<\/jats:italic>= 0.79). PS can infrequently proliferate aggressively with more differentiated features. Loss of membranous \u03b2\u2010catenin expression may be associated with PS of HCC.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2011.02669.x","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T06:57:19Z","timestamp":1303887439000},"page":"356-362","source":"Crossref","is-referenced-by-count":22,"title":["Peritoneal seeding of hepatocellular carcinoma: Clinicopathological characteristics of 17 autopsy cases"],"prefix":"10.1111","volume":"61","author":[{"given":"Susumu","family":"Matsukuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,27]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"159","volume-title":"World Health Organization Classification of Tumours, Pathology and Genetics, Tumours of the Digestive System","author":"Hirohashi S","year":"2000"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24687"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.06.021"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830301)51:5<863::AID-CNCR2820510520>3.0.CO;2-D"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901115)66:10<2174::AID-CNCR2820661022>3.0.CO;2-A"},{"key":"e_1_2_6_7_2","first-page":"239","article-title":"An autopsy study of hepatocellular carcinoma with peritoneal metastasis","volume":"12","author":"Saito K","year":"1994","journal-title":"Byori Rinshou"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.3.r00se24698"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01897.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3927"},{"key":"e_1_2_6_11_2","first-page":"1183","article-title":"An autopsy case of hepatocellular carcinoma in which sarcoma\u2010like changes and peritoneal dissemination were observed after RFA\/TACE treatment","volume":"36","author":"Obara A","year":"2009","journal-title":"Jpn J Cancer Chemother"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.3919\/jjsa.70.1804"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930410310"},{"key":"e_1_2_6_14_2","first-page":"67","article-title":"Spontaneous rupture of hepatocellular carcinoma: A review of 172 Japanese cases","volume":"86","author":"Miyamoto M","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02483040"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005340070025"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02557522"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909089239"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.178.1.1984314"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24233"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.118.3.681"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010701)92:1<136::AID-CNCR1301>3.0.CO;2-R"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24254"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/hp.2000.6683"},{"key":"e_1_2_6_25_2","first-page":"921","article-title":"Prognostic significance of \u03b2\u2010catenin nuclear expression in hepatocellular carcinoma","volume":"51","author":"Fujito T","year":"2004","journal-title":"Hepato-Gastroenterol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i16.2398"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2011.02669.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2011.02669.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:31:20Z","timestamp":1698730280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2011.02669.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,27]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1440-1827.2011.02669.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2011.02669.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,27]]}}}