{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:45:10Z","timestamp":1778319910285,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T00:00:00Z","timestamp":1305504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm of low malignant potential that mainly affects infants and adolescents. The tumor almost exclusively occurs in somatic soft tissue or the retroperitoneum. We report herein two cases of primary KHE occurring in a long bone without cutaneous changes with long\u2010term follow up in young patients. The patients were a 9\u2010year\u2010old girl and 5\u2010year\u2010old boy presenting with lytic lesions of the femur and humerus, respectively, without cutaneous lesions. Histologically, the neoplasms were comprised of nodules of spindle\u2010 to oval\u2010shaped cells growing in an infiltrative fashion. The neoplastic cells formed poorly canalized or slit\u2010like blood vessels alternating with solid spindle areas. Immunohistochemical studies showed that the tumor cells expressed CD31, CD34 and Fli1, but not HHV8, LNA\u20101 or GLUT1. D2\u201040 stained the neoplastic spindle cells and lymphatic channels adjacent to vascular lobules. The girl remains well with 15\u2003years and 6\u2003months follow up after a second complete excision. The boy has no signs of recurrence or metastasis nearly 5\u2003years after local complete excision. To our best knowledge, this is the first report in the English literature of primary long bone occurrences of KHE without cutaneous changes with long\u2010term follow up.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2011.02681.x","type":"journal-article","created":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T08:38:48Z","timestamp":1305535128000},"page":"382-386","source":"Crossref","is-referenced-by-count":14,"title":["Primary kaposiform hemangioendothelioma of a long bone: Two cases in unusual locations with long\u2010term follow up"],"prefix":"10.1111","volume":"61","author":[{"given":"Jie","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun\u2010li","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang\u2010bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199304000-00001"},{"key":"e_1_2_6_3_2","volume-title":"Enzinger and Weiss's Soft Tissue Tumors","author":"Weiss SW","year":"2001"},{"key":"e_1_2_6_4_2","volume-title":"Pathology and Genetics of Tumours of Soft Tissue and Bone","author":"Fletcher CDM","year":"2002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199303000-00015"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513818909026915"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2008.06.008"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000176539.94515.75"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.880"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/96.5.660"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002470100009"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200405000-00001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880441"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199711000-00001"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0838-2"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80192-6"},{"key":"e_1_2_6_17_2","first-page":"559","article-title":"A unique microvascular phenotype shared by juvenile hemangiomas and human placenta","volume":"137","author":"North PE","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00461.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800444"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/106689699400200111"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1309\/B8TC0LBVH8XY5MFV"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2011.02681.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2011.02681.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:31:28Z","timestamp":1698730288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2011.02681.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,16]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1440-1827.2011.02681.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2011.02681.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,16]]}}}