{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:28:14Z","timestamp":1774121294517,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T00:00:00Z","timestamp":1310342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>IgG4\u2010related sclerosing disease (IgG4\u2010RSD) is an inflammatory and fibrosing disorder characterized by lymphoplasmacytic inflammation with infiltration of various organs, including the pancreas, bile ducts, lung, kidney, and retroperitoneum. As for malignancy in IgG4\u2010RSD, only limited literature is available. We report here a case of thyroid papillary carcinoma showing unique morphology in IgG4\u2010RSD. Solid tumor nests were surrounded by dense IgG4\u2010positive plasma cells and fibrosis at both the primary site and metastatic lymph nodes. In contrast the background thyroid showed focal lymphocytic thyroiditis. IgG4\u2010related sclerosing sialadenitis and autoimmune pancreatitis were also diagnosed, and prednisolone treatment improved symptoms and serum IgG4 abnormality. To the best of our knowledge, this is the first documentation of a malignancy of the thyroid gland occurring in a background of IgG4\u2010RSD. A brief review of the literature on the relationship between IgG4 and malignancy is included.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2011.02701.x","type":"journal-article","created":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T09:50:42Z","timestamp":1310377842000},"page":"589-592","source":"Crossref","is-referenced-by-count":20,"title":["Thyroid papillary carcinoma with solid sclerosing change in IgG4\u2010related sclerosing 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