{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:45:58Z","timestamp":1772808358120,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T00:00:00Z","timestamp":1314662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Composite lymphoma is defined as two or more distinct types of lymphoma in a single anatomical site. Among various combinations, composite B\u2010cell and T\u2010cell non\u2010Hodgkin's lymphomas (CBTL) are very infrequent. Herein we describe a 66\u2010year\u2010old female with CBTL presenting with lymphadenopathy, multiple bone lesions and an epidural tumor. Light microscopic examination of a biopsied cervical node revealed a dual population of lymphoid cells: sheets of large cells admixed with medium\u2010sized cells. The large cells expressed B\u2010cell markers and showed immunoglobulin light chain restriction, consistent with diffuse large B\u2010cell lymphoma (DLBCL). The medium\u2010sized cells were positive for CD20 as well as T\u2010cell markers. Because polymerase chain reaction amplification showed monoclonal rearrangement of the T\u2010cell receptor \u03b2 chain gene, this population was compatible with peripheral T\u2010cell lymphoma not otherwise specified (PTCL\u2010NOS). We therefore made a diagnosis of composite DLBCL and CD20\u2010positive PTCL\u2010NOS. Complete remission was achieved after six cycles of R\u2010CHOP regimen (rituximab, doxorubicin, vincristine, cyclophosphamide and prednisolone). This is the first report of CD20\u2010positive PTCL\u2010NOS associated with composite lymphoma. Moreover, a literature review of composite DLBCL and PTCL\u2010NOS indicates that this rare clinical entity may be featured by efficacy of systemic chemotherapy in spite of prevalent extranodal lesions.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2011.02713.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T06:01:27Z","timestamp":1314856887000},"page":"662-666","source":"Crossref","is-referenced-by-count":5,"title":["Composite diffuse large B\u2010cell lymphoma and CD20\u2010positive peripheral T\u2010cell lymphoma"],"prefix":"10.1111","volume":"61","author":[{"given":"Sho","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosei","family":"Fujioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Shinozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Kamikubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Nannya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoshi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Fukayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mineo","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,30]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"CusterRP.Pitfalls in the diagnosis of lymphoma and leukemia from the pathologist's point of view.Proceedings of the second National Cancer Conference New York American Cancer Society 1954:554\u201357."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197709)40:3<959::AID-CNCR2820400302>3.0.CO;2-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1309\/P6LUADHRL9TXFW2M"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600763348"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2006.060016"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1309\/6UTX-GVC0-12ND-JJEU"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/QBLAMA321K9AD2XK"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990140212"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1989.tb00514.x"},{"key":"e_1_2_5_11_2","first-page":"29","article-title":"Monoclonal antibodies marking B\u2010cell non\u2010Hodgkin's lymphoma in paraffin\u2010embedded tissue","volume":"1","author":"Linder J","year":"1988","journal-title":"Mod Pathol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.12.1405"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817d7452"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1309\/72CM-KAXF-66DE-4XVA"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06725.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11269"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2011.02713.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2011.02713.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T23:50:25Z","timestamp":1698709825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2011.02713.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,30]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1440-1827.2011.02713.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2011.02713.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,30]]}}}