{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T04:53:12Z","timestamp":1698727992341},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T00:00:00Z","timestamp":1316736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>We present a case of atypical idiopathic retroperitoneal fibrosis (iRPF) presenting as a large pelvic tumor, for which it proved difficult to exclude T\u2010cell malignant lymphoma. Histopathological examination of biopsy material showed collagenous tissue and fat with an exuberant and predominant T\u2010cell infiltrate, largely consisting of CD4<jats:sup>+<\/jats:sup> cells expressing the IL\u20102 receptor\u2010\u03b1 chain (CD25). Focal plasma cells were negative for the immunoglobulin G4 (IgG4) isotype. T\u2010cell receptor gene rearrangement (TRGR) pattern showed a Gaussian distribution, in keeping with a polyclonal T\u2010cell population. Awareness of the sometimes exuberant and predominant T\u2010cell infiltrate in iRPF should lead to earlier consideration of this disorder. This is particularly the case where there is an atypically localized and\/or extensive mass, for which early exclusion of monoclonality with TRGR may provide helpful. Immunohistochemical findings suggest that CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> cells, which are part of a naturally occurring population of regulatory T\u2010cells, may be involved in the pathogenesis of iRPF.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2011.02718.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T22:51:59Z","timestamp":1317163919000},"page":"672-676","source":"Crossref","is-referenced-by-count":3,"title":["Idiopathic retroperitoneal fibrosis mimicking malignant lymphoma"],"prefix":"10.1111","volume":"61","author":[{"given":"Eric F. 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