{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:09:46Z","timestamp":1790647786934,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:00:00Z","timestamp":1319587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>A comparison of the efficacy of the copper chelator, trientine, with combined renin angiotensin system (RAS) blockade on the progression of glomerular pathology in the diabetic (mREN\u20102)27 rat is reported. Animals were treated for 2\u2003months with trientine, combined RAS blockers, combined trientine plus RAS blockers or none. Treatments began after inducing diabetes with streptozotocin. Physiological data were recorded monthly and light microscopic glomerular features were scored. Plasma allantoin and both plasma and renal protein carbonyls were measured as markers of oxidative stress. Trientine and RAS blockade decreased proteinuria and albuminuria and prevented an increase in creatinine clearance and kidney weight. Both reduced the diabetes\u2010related glomerular features of mesangiolysis and glomerular segmental hypocellularity and trientine prevented severe tuft\u2010to\u2010capsule adhesion and reduced tubularization. Hypertension\u2010related severe mesangial matrix expansion and global hypercellularity were increased by both treatments, which may reflect repair of mesangiolysis. Trientine reduced plasma but not renal protein carbonyls or plasma allantoin. In this model, trientine prevented the development of many diabetes\u2010specific features similarly to RAS blockade. Amelioration of oxidative stress and features commonly observed in human diabetic nephropathy (DN), support a diabetes\u2010related defect in copper (Cu) metabolism. The addition of Cu<jats:sup>II<\/jats:sup> chelation may improve current DN therapy<\/jats:p>","DOI":"10.1111\/j.1440-1827.2011.02721.x","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T02:04:53Z","timestamp":1319681093000},"page":"652-661","source":"Crossref","is-referenced-by-count":7,"title":["Trientine and renin\u2013angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy"],"prefix":"10.1111","volume":"61","author":[{"given":"Leire","family":"Moya\u2010Olano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Marie","family":"Milne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian Margaret","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Vernon","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Miles","family":"Frampton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Frances","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufus","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony James","family":"Kettle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n Huba","family":"Endre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035592"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/94.2.89"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00159.2003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043383052"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808400"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.9.2501"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200780098"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715769109145775"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200900285"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200600770"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1088-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.10.2603"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00019.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.512"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00727.2009"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.96"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/32.7.294"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1081\/IAS-120027228"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00104-4"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.172460"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.09205.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1983.119"},{"key":"e_1_2_6_25_2","first-page":"147","article-title":"Mesangiolysis","volume":"7","author":"Leontsini M","year":"2003","journal-title":"Hippokratia"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9531171"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.272"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdip.2003.09.001"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780392"},{"key":"e_1_2_6_30_2","first-page":"265","article-title":"The Relationship Between the Clinical and the Histological Features of Acute Glomerular Nephritis: Based on a Study of Renal Biopsy Material","volume":"27","author":"Hutt MSR","year":"1958","journal-title":"QJM"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000097017"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(03)00003-2"},{"key":"e_1_2_6_33_2","first-page":"S99","article-title":"Human studies related to protein oxidation: Protein carbonyl content as a marker of damage","volume":"33","author":"Chevion M","year":"2000","journal-title":"Free Radic Res"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00185-0"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.028605"},{"key":"e_1_2_6_36_2","first-page":"1321","article-title":"Enzymes involved in purine metabolism\u2013a review of histochemical localization and functional implications","volume":"14","author":"Moriwaki Y","year":"1999","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000258415.32883.bf"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2011.02721.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2011.02721.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T23:50:16Z","timestamp":1698709816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2011.02721.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,26]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1440-1827.2011.02721.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2011.02721.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,26]]}}}