{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:22:54Z","timestamp":1761895374648},"reference-count":66,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:00:00Z","timestamp":1319587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Almost 70\u2003years after the description of \u2018collagen disease\u2019 by P. Klemperer <jats:italic>et\u2003al<\/jats:italic>., it is still controversial whether the diversity and similarity of pathological manifestations among the collagen diseases depends on ambiguity in diagnosis or is an intrinsic quality of the collagen diseases themselves. A genome wide analysis of the MRL mouse models of collagen disease may shed some light on the complex pathological manifestations. Study of the susceptibility loci to each type ofcollagen disease (such as glomerulonephritis, vasculitis, arthritis, sialoadenitis and dacryoadenitis) in the mice, revealed that these lesions developed because of a cumulative effect of multiple gene loci, none of which can induce the related phenotype alone. This may indicate that collagen disease develops in \u2018a polygenic system\u2019, as proposed by K. Mather in 1949. Each lesion in the mice developed because of an additive effect of the polygenes, which is also, in part, hierarchical. Some of the polygenes seemed to be common to those in other collagen diseases as well. Some of the positional candidate genes involved an allelic polymorphism in the coding or promoter regions, thus possibly causing a qualitative or quantitative difference in their function, respectively. As a result, a particular combination of the polygenes with such an allelic polymorphism may thus play a critical role in leading the cascade reaction to developing collagen disease, and also the regular variation in the pathological manifestations. We herein describe this as a polygene network of collagen disease.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2011.02725.x","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T22:04:53Z","timestamp":1319666693000},"page":"619-629","source":"Crossref","is-referenced-by-count":8,"title":["A polygene network model for the complex pathological phenotypes of collagen disease"],"prefix":"10.1111","volume":"61","author":[{"given":"Masato","family":"Nose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,26]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1942.02830210023006"},{"key":"e_1_2_12_3_2","first-page":"321","article-title":"The \u2018overlap syndrome\u2019 (Rheumatoid arthritis with features of systemic lupus): An 8\u2010year follow\u2010up with 2 postmortems","volume":"5","author":"Silver M","year":"1962","journal-title":"Arthritis Rheum"},{"key":"e_1_2_12_4_2","first-page":"207","volume-title":"Genetic Control of Autoimmune Disease","author":"Murphy ED","year":"1978"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1198"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.5.1302"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(80)90065-3"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271013"},{"key":"e_1_2_12_9_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4049\/jimmunol.133.1.227","article-title":"Induction of various autoantibodies by mutant gene lpr in several strains of mice","volume":"133","author":"Izui S","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60342-9"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199807)28:07<2217::AID-IMMU2217>3.0.CO;2-P"},{"key":"e_1_2_12_12_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4049\/jimmunol.141.1.118","article-title":"Novel and enhanced IL\u20101 gene expression in autoimmune mice with lupus","volume":"141","author":"Boswell JM","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.3.273"},{"key":"e_1_2_12_14_2","first-page":"255","article-title":"Increased macrophage colony\u2010stimulating factor in neonatal and adult autoimmune MRL\u2010lpr mice","volume":"139","author":"Yui MA","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_12_15_2","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.129.6.2612","article-title":"Abnormalities induced by the mutant gene lpr: Expansion of unique lymphocyte subset","volume":"0129","author":"Morse HC","year":"1982","journal-title":"J Immunol"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.6.1690"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280511"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300110"},{"key":"e_1_2_12_19_2","first-page":"511","article-title":"Pathogenic significance of serum components in the development of autoimmune polyarthritis in MRL\/Mp mice bearing the lymphoproliferation gene","volume":"139","author":"Itoh J","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_12_20_2","first-page":"611","article-title":"Sialadenitis in the MRL\/l mouse: Morphological and immunohistochemical characterization of resident and infiltrating cells","volume":"60","author":"Jonsson R","year":"1987","journal-title":"Immunology"},{"key":"e_1_2_12_21_2","first-page":"229","article-title":"Systemic mononuclear\u2010cell vasculitis in MRL\/Mp\u2010lpr\/lpr mice: A histologic and immunocytochemical analysis","volume":"127","author":"Moyer CF","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1996.d01-814.x"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270206"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb06879.x"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/356314a0"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.5.1747"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1756"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60672-0"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/373438a0"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/376181a0"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.24.11225"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.159.1.1"},{"key":"e_1_2_12_33_2","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.4049\/jimmunol.136.11.4075","article-title":"Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H\u2010lpr\/lpr and C3H\u2010gld\/gld mice","volume":"136","author":"Davidson WF","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.001331"},{"key":"e_1_2_12_35_2","first-page":"271","article-title":"Analysis of granulomatous arteritis in MRL\/Mp autoimmune disease mice bearing lymphoproliferative genes. The use of mouse genetics to dissociate the development of arteritis and glomerulonephritis","volume":"135","author":"Nose M","year":"1989","journal-title":"Am J Pathol"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.5.1367"},{"key":"e_1_2_12_37_2","first-page":"145","volume-title":"Intractable Vasculitis Syndromes","author":"Nose M","year":"1993"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90375-1"},{"key":"e_1_2_12_39_2","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.4049\/jimmunol.154.8.3806","article-title":"Expression of the Fas ligand in cells of T cell lineage","volume":"154","author":"Suda T","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400610"},{"key":"e_1_2_12_41_2","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.4049\/jimmunol.146.12.4138","article-title":"Cytokine secretion by C3H\u2010lpr and \u2010gld T cells: Hypersecretion of IFN\u2010\u03b3 and tumor necrosis factor\u2010\u03b1 by stimulated CD4+ T cells","volume":"146","author":"Davidson WF","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830251034"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260114"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06024.x"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.12.1793"},{"key":"e_1_2_12_46_2","first-page":"1115","article-title":"Systemic lupus erythematosus","volume":"5","author":"Dixon FJ","year":"1983","journal-title":"Prog Immunol"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2003.01516.x"},{"key":"e_1_2_12_48_2","first-page":"1763","article-title":"Arteritis in a novel congenic strain of mice derived from MRL\/lpr lupus mice: Genetic dissociation from glomerulonephritis and limitted autoantibody production","volume":"149","author":"Nose M","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_12_49_2","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.4049\/jimmunol.130.4.1699","article-title":"Analysis of vascular lesions in murine SLE. I. Association with serologic abnormalities","volume":"130","author":"Berden JHM","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_12_50_2","first-page":"53","article-title":"SCG\/Kj mice develop crescentic glomerulonephritis, vasculitis and MPO\u2010specific P\u2010ANCA","volume":"101","author":"Kinjoh K","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02245.x"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-241"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200007)30:7<2027::AID-IMMU2027>3.0.CO;2-S"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199912)42:12<2616::AID-ANR16>3.0.CO;2-O"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10193"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3132"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10952"},{"key":"e_1_2_12_58_2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.4049\/jimmunol.149.3.880","article-title":"Extensive polymorphism in the extracellular domain of the mouse B cell differentiation antigen Lyb\u20102\/CD72","volume":"149","author":"Robinson WH","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425672"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80124-7"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(95)00053-H"},{"key":"e_1_2_12_62_2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.4049\/jimmunol.147.2.515","article-title":"IgG3 production in MRL\/lpr mice is responsible for development of lupus nephritis","volume":"147","author":"Takahashi S","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb03666.x"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179407"},{"key":"e_1_2_12_65_2","first-page":"1436","article-title":"Induction of different types of glomerulonephritis by monoclonal antibodies derived from MRL\/lpr lupus mouse","volume":"143","author":"Itoh J","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90376-4"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2011.02725.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2011.02725.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T19:50:53Z","timestamp":1698695453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2011.02725.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,26]]},"references-count":66,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1440-1827.2011.02725.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2011.02725.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,26]]}}}