{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:28:29Z","timestamp":1792247309178,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T00:00:00Z","timestamp":1326412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>Mucosa\u2010associated lymphoid tissue (MALT) lymphoma arising in the thymus is a rare disorder that shows a strong association with autoimmune disease. Several MALT\u2010lymphoma\u2010specific and \u2010associated chromosomal abnormalities, including t(11;18), t(14;18), t(1;14), trisomy 3 and trisomy 18, are known to occur. The former translocation results in apoptosis inhibitor 2 gene (<jats:italic>API2<\/jats:italic>)\u2013MALT lymphoma\u2010associated translocation 1 (<jats:italic>MALT1<\/jats:italic>) fusion. In this study, we examined 14 cases of thymic MALT lymphomas for <jats:italic>API2\u2013MALT1<\/jats:italic> fusion using multiplex reverse transcription polymerase chain reaction and looked for trisomy 3, trisomy 18 and abnormalities of <jats:italic>MALT1<\/jats:italic> and <jats:italic>IGH<\/jats:italic> genes using fluorescence <jats:italic>in situ<\/jats:italic> hybridization. Thymic MALT lymphoma cases had a high frequency of trisomy 3 (7\/14 cases), a very low incidence of trisomy 18 (1\/14) and no detectable <jats:italic>MALT1<\/jats:italic>\u2010associated (0\/13) or <jats:italic>IGH<\/jats:italic>\u2010associated (0\/13) gene abnormalities including t(11;18). A review of the literature showed that the pattern of chromosomal aberrations in thymic MALT lymphoma was similar to those of thyroid and salivary gland MALT lymphomas. Although frequently detected, trisomy 3 was not associated with any of the clinicopathological factors analyzed, suggesting that trisomy 3 may play a role in lymphoma development. In conclusion, the present study showed that thymic MALT lymphoma has a characteristic pattern of chromosomal aberrations that may be similar to those of other autoimmune\u2010associated MALT lymphomas.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2011.02764.x","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T07:12:13Z","timestamp":1326438733000},"page":"93-98","source":"Crossref","is-referenced-by-count":20,"title":["Characterization of chromosomal aberrations in thymic MALT lymphoma"],"prefix":"10.1111","volume":"62","author":[{"given":"Satoru","family":"Kominato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Fujiyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,13]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"214","volume-title":"World Health Organization Classification of Tumours. 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