{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:39:00Z","timestamp":1772638740674,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T00:00:00Z","timestamp":1329177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Schneiderian papilloma (SP) is classified into three types: inverted, oncocytic, and exophytic. Malignant transformation occurs in 10% of SP; most are inverted and oncocytic types. Malignant transformation of polypoid exophytic SP is exceptional; only two cases have been reported in the English literature. A 58\u2010year\u2010old man consulted our hospital because of nasal obstruction. Nasal endoscopy and imaging modalities showed a polyp in the right nasal cavity. Biopsy findings showed compatibility with SP. However, since fludeoxyglucose positron emission tomography (FDG\u2010PET) showed signals, polypectomy was performed. Grossly, the polyp was reddish white and measured 2\u2003cm. Histologically, the polyp consisted of a non\u2010invasive squamous cell carcinoma (SCC) component (70%), a mature squamous component (20%), and Schneiderian epithelium (10%). Vague koilocytosis was present in the SCC component. The three components were arranged in an exophytic papillary pattern. Immunohistochemically, the non\u2010invasive SCC component was positive for cytokeratins (AE1\/3, CAM5.2, CK5\/6), p63, p53, and Ki67 (labeling 50%). The mature squamous component was positive for cytokeratins (AE1\/3, CAM5.2 and CK5\/6), p63, and Ki67 (labeling 6%). The Schneiderian component was positive for cytokeratins (AE1\/3, CAM5.2, and CK5\/6), p63, and Ki\u201067 (labeling 4%). The tumor was HPV negative in the three components. The polyp was diagnosed as exophytic Schneiderian carcinoma arising from exophytic SP. The patient is now free from tumor 4\u2003years after the operation.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2012.02795.x","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T07:40:49Z","timestamp":1329205249000},"page":"199-203","source":"Crossref","is-referenced-by-count":10,"title":["Malignant transformation of exophytic Schneiderian papilloma of the nasal cavity"],"prefix":"10.1111","volume":"62","author":[{"given":"Tadashi","family":"Terada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,14]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"28","volume-title":"World Health Organization Classification of Tumours. 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