{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:09:58Z","timestamp":1792098598074,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>A 68\u2010year\u2010old woman was diagnosed with mature cystic teratoma of the left ovary when she was 44\u2003years old. The tumor recently enlarged rapidly, and abdominal magnetic resonance imaging revealed an intrapelvic cystic lesion, which measured 123 \u00d7 120 \u00d7 107\u2003mm and contained a mural nodule. Under a clinical diagnosis of malignant transformation of mature cystic teratoma, bilateral salpingo\u2010oophorectomy with total hysterectomy and omentectomy were performed. The resected specimen showed a unilocular cystic lesion containing a well\u2010demarcated mural nodule measuring 35 \u00d7 30 \u00d7 25\u2003mm in the left ovary. A microscopic examination revealed various types of carcinoma in the mural nodule: pulmonary type small cell carcinoma (65%), adenocarcinoma (25%), squamous cell carcinoma (5%), and transitional cell carcinoma (5%). Small cell carcinoma was positive for CD56, synaptophysin, and chromogranin A. The adenocarcinoma component showed intestinal phenotypes; i.e. cytokeratin (CK) 7(\u2212), CK20(+), CDX2(+), estrogen receptor(\u2212), and progesterone receptor (\u2212). Interestingly, CDX2 positivity was retained in all of the carcinomas. It was assumed that the adenocarcinoma had arisen from an intestinal epithelium in the mature cystic teratoma and then differentiated into the diverse histological types mentioned above.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2012.02804.x","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T07:59:32Z","timestamp":1330415972000},"page":"276-280","source":"Crossref","is-referenced-by-count":27,"title":["Malignant transformation of ovarian mature cystic teratoma with a predominant pulmonary type small cell carcinoma component"],"prefix":"10.1111","volume":"62","author":[{"given":"Hayato","family":"Ikota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kou","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachio","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsue","family":"Kawarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Yokoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"World Health Organization Classification of Tumours of the Breast and Female Genital Organs","author":"Tavassoli FA","year":"2003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-006-0244-x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70306-1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(92)90265-K"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1998.tb03846.x"},{"key":"e_1_2_6_7_2","first-page":"973","article-title":"Ovarian neuroendocrine carcinoma associated with mucinous carcinoma and teratoma","volume":"62","author":"Hirasawa T","year":"2004","journal-title":"Nippon Rinsho"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213422.53750.d1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2009.01.013"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.1994.9.5.432"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31819d4574"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318211f56e"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2006.12.010"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181929269"},{"key":"e_1_2_6_15_2","first-page":"187","article-title":"Glioblastoma multiforme in a dermoid cyst of the ovary. 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