{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:29:35Z","timestamp":1769923775284,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T00:00:00Z","timestamp":1336003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>This report describes a case of an immunocompetent 77\u2010year\u2010old male with Epstein\u2010Barr virus (EBV)\u2010positive lymphoproliferative disorder associated with calcified chronic subdural hematoma (CSH). On the day prior to consultation in our outpatient clinic, the patient fell from his bed, striking his frontal head on the floor. Magnetic resonance imaging showed ill\u2010defined lesions in the right frontal\u2010temporal subdural regions. At surgery, a hard and thickened outer membrane of a CSH and muddy organized subdural hematoma were observed. However, macroscopic neoplastic lesions were not apparent. Histologically, there were atypical lymphoid cells scattered or conglomerated in some areas of the thick outer membrane of the CSH. They were composed of occasional large atypical lymphoid cells. The lesions were accompanied by necrosis. Atypical lymphoid cells were immunopositive for B\u2010cell markers but not for T\u2010cell markers. EBNA2 was seen in the nuclei of tumor cells. Atypical lymphoid cells showed positive signals for EBV\u2010encoded small RNAs (EBERs) on <jats:italic>in situ<\/jats:italic> hybridization. These findings were consistent with EBV\u2010positive lymphoproliferative disorder associated with CSH. These results also suggested that EBV and the inflammatory reaction found in the CSH could be the etiological factors in the pathogenesis of lymphoproliferative disorder.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2012.02824.x","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T03:03:11Z","timestamp":1336100591000},"page":"412-417","source":"Crossref","is-referenced-by-count":14,"title":["Epstein\u2010Barr virus\u2010positive lymphoproliferative disorder associated with old organized chronic subdural 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