{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:35:47Z","timestamp":1791182147122,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>t(14;18) is a common cytogenetic abnormality in B\u2010cell lymphoma, especially in follicular lymphoma (FL), but is rarely seen in Hodgkin's lymphoma (HL). However, due to the small number of cases, the incidence of t(14;18) in HL associated with FL remains unclear. In this study, we applied chromogenic <jats:italic>in situ<\/jats:italic> hybridization and fluorescence <jats:italic>in situ<\/jats:italic> hybridization for t(14;18) on paraffin\u2010embedded tissue from four HL associated with FL cases and 11 HL cases without a history of FL for comparison. t(14;18) was present in all of the three successfully\u2010tested HL associated with FL cases and one case without a history of FL. The frequency of t(14;18) was significantly high in HL associated with FL (<jats:italic>p<\/jats:italic>\u2003=\u20030.013). All Hodgkin's and Reed\u2010Sternberg (HRS) cells having t(14;18) showed immunoreactivity for BCL2 and were negatively stained for nuclear factor\u2010\u03baB (NF\u2010\u03baB), even in Epstein\u2010Barr virus (EBV)\u2010infected cases. However, HRS cells without t(14;18) showed BCL2 and NF\u2010\u03baB immunoreactivity in 33% and 57% of cases, respectively. There was an inverse correlation between t(14;18) and NF\u2010\u03baB. In conclusion, we assume the incidence of t(14;18) in HL associated with FL is higher than previously believed and BCL2 expression derived from t(14;18) may play a role in the pathogenesis of HL associated with FL.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2012.02835.x","type":"journal-article","created":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T13:12:48Z","timestamp":1340716368000},"page":"518-524","source":"Crossref","is-referenced-by-count":17,"title":["High frequency of t(14;18) in Hodgkin's lymphoma associated with follicular 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