{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:34:31Z","timestamp":1789014871134,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Composite lymphomas (CLs) have been reported in 1\u20134.7% of all lymphomas, however, CLs containing both T\u2010 and B\u2010cell lymphomas (CTBLs) are very rare. Here, we examined the clinical and pathological features of 29 CTBLs. These CTBLs included 21 patients with angioimmunoblastic T\u2010cell lymphoma (AITL) and diffuse large B\u2010cell lymphoma (DLBCL), two with adult T\u2010cell leukemia\/lymphoma and DLBCL, one with AITL and Follicular lymphoma, one with Lennert lymphoma and DLBCL, one with subcutaneous panniculitis\u2010like T\u2010cell lymphoma and DLBCL, one with peripheral T\u2010cell lymphoma (PTCL) and DLBCL, one with cutaneous T\u2010cell lymphoma and DLBCL, and one with PTCL and chronic lymphocytic leukemia. Eighteen of 27 patients (67%) were shown to be Epstein\u2010Barr virus (EBV)\u2010encoded RNA\u2010positive in their B\u2010cell lymphoma component. T\u2010cell and B\u2010cell clonality were confirmed by flow cytometry, Southern blot analysis, and\/or polymerase chain reaction (PCR). Using Southern blot analysis, clonal immunoglobulin heavy chain (IgH) and T\u2010cell receptor (TCR) rearrangements were detected in 11 of 21 and 15 of 24 cases, respectively. Using PCR analysis, clonal IgH and TCR rearrangements were detected in 7 of 8 and 7 of 7 Southern blot\u2010negative cases, respectively. Our results suggested that PCR analysis was useful in diagnosing CTBL.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2012.02858.x","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T07:37:10Z","timestamp":1348558630000},"page":"690-698","source":"Crossref","is-referenced-by-count":59,"title":["Clinicopathological analysis of a composite lymphoma containing both T\u2010 and B\u2010cell lymphomas"],"prefix":"10.1111","volume":"62","author":[{"given":"Nobuko","family":"Suefuji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Niino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennosuke","family":"Karube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshizo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Kiyasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.5858\/2000-124-1376-AUVOCL","article-title":"An unusual variant of composite lymphoma: A short case report and review of the literature","volume":"124","author":"Thirumala S","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_3_2","unstructured":"CusterR.Pitfalls in the diagnosis of lymphoma and leukemia from the pathologist's point of view. 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