{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T05:10:39Z","timestamp":1697346639732},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,2,24]],"date-time":"2004-02-24T00:00:00Z","timestamp":1077580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p><jats:bold>Objective:\u2003<\/jats:bold> Central sleep apnoea (CSA) in patients with heart failure is associated with an extremely poor prognosis. It is unclear as to whether pulmonary congestion contributes to CSA.<\/jats:p><jats:p><jats:bold>Methodology:\u2003<\/jats:bold> We developed a sheep model of congestive cardiac failure (CCF) to address the question of whether pulmonary congestion without hypocapnia could cause CSA. Fourteen lambs were given CCF by overdrive pacing for 3 weeks. CCF was defined by a pulmonary artery occlusion pressure (PAOP)\u2003\u2265\u200315\u2003mmHg. There were 11 controls. Extravascular lung water (EVLW) was measured by the double indicator dilution method.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> The CCF lambs had a PAOP = 18\u2003\u00b1 3\u2003mmHg and controls had a PAOP = 10\u2003\u00b1\u20032\u2003mmHg (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). EVLW was 12.6\u2003\u00b1\u20031.8 (CCF) compared to 8.9\u2003\u00b1\u20032\u2003mL\/kg (controls) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). The respiratory rate was 74\u2003\u00b1\u200321 b.p.m. (CCF) compared to 47\u2003\u00b1\u20036 b.p.m. (controls) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Acute volume loading with saline raised PAOP without changing respiration. pH and PaCO<jats:sub>2<\/jats:sub> were the same in both groups (PaCO<jats:sub>2<\/jats:sub>\u221237\u2003mmHg).<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> These results support the view that hypocapnia is essential for CSA, and demonstrated that increased EVLW causes tachypnoea but not CSA.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2003.00537.x","type":"journal-article","created":{"date-parts":[[2004,2,24]],"date-time":"2004-02-24T14:27:50Z","timestamp":1077632870000},"page":"60-65","source":"Crossref","is-referenced-by-count":2,"title":["Increased lung water without hypocapnia does not cause central sleep apnoea in a lamb model"],"prefix":"10.1111","volume":"9","author":[{"given":"Keith R.","family":"Burgess","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Berend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542128"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/15.suppl_B.20"},{"key":"e_1_2_6_4_2","unstructured":"BurgessK.Central sleep apnoea and left ventricular failure.PhD Thesis University of Sydney Sydney 2001."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.4.1079"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.2.330"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008877"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.6.8520745"},{"key":"e_1_2_6_9_2","first-page":"687","article-title":"A randomised controlled clinical trial of CPAP in patients with heart failure and Cheyne\u2010Stokes respiration. 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