{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:17:01Z","timestamp":1697271421576},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T00:00:00Z","timestamp":1154563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Background:\u2003<\/jats:bold> Bronchial hyperresponsiveness and\/or bronchospasm are recognized complications of sickle cell disease.<\/jats:p><jats:p><jats:bold>Objective:\u2003<\/jats:bold> The aim of this study was to investigate the presence of bronchospasm during painful crises, using simple spirometry in patients with sickle cell disease.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> A prospective, non\u2010randomized study was undertaken in patients with homozygous sickle cell disease, who presented with increasing pain. A painful crisis was defined as any increase in bodily pains necessitating hospital admission. A 15% increase in FEV<jats:sub>1<\/jats:sub> following salbutamol nebulization was considered significant.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Thirty\u2010nine patients took part in the study. Significant bronchodilator responses were demonstrable in 48.7% of patients during painful crises. Patients with such a response had a significantly lower peripheral blood eosinophil count (mean count 0.17\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L vs. 0.445\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L, <jats:italic>P<\/jats:italic>\u2003=\u20030.02, confidence interval for difference between groups, 0.0, 0.39). Furthermore, the magnitudes of the bronchodilator responses were related to the degree of lowering of peripheral blood eosinophil counts (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2003=\u2003\u22120.344, <jats:italic>P<\/jats:italic>\u2003=\u20030.037).<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Significant bronchospasm is demonstrable in a sizeable proportion of patients presenting with painful sickle cell crises. There seems to be a negative correlation between the magnitude of bronchospasm and the peripheral blood eosinophil count. We postulate a possible role for pulmonary sequestration of eosinophils in the pathophysiology of bronchospasm in sickle cell disease patients.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2006.00900.x","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T09:46:27Z","timestamp":1154598387000},"page":"633-637","source":"Crossref","is-referenced-by-count":4,"title":["Significant bronchospasm during sickle cell painful crises is associated with a lower peripheral eosinophil count"],"prefix":"10.1111","volume":"11","author":[{"given":"Hilali","family":"HASSAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inam","family":"MUGHAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javeed","family":"DAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taj E.","family":"AL MEKKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zivani","family":"CHAPUNDUKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"HADDAD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imad S. A.","family":"HASSAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,3]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"220","article-title":"Comprehensive care in sickle cell disease: its impact on morbidity and mortality","volume":"28","author":"Vichinsky EP","year":"1991","journal-title":"Semin. Hematol."},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1182\/blood.V89.5.1787","article-title":"Disease cooperative study of sickle cell: acute chest Syndrome in sickle cell disease: clinical presentation and course","volume":"89","author":"Vichinsky EP","year":"1997","journal-title":"Blood"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6342.633"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.111824"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70166-5"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200103000-00009"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02157-7"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.5.1555"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.4.H1579"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.1.9611085"},{"key":"e_1_2_5_13_2","first-page":"412","article-title":"Elevated serum levels of free fatty acids in sickle cell disease patients with the acute chest syndrome and acute multi\u2010organ failure syndrome","volume":"84","author":"Hassell KL","year":"1994","journal-title":"Blood"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(200005)64:1<15::AID-AJH3>3.0.CO;2-P"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1182\/blood.V91.1.266","article-title":"Blood polymorphonuclear leucocytes from the majority of sickle cell patients in crisis phase of the disease show enhanced adhesion to vascular endothelium and increased expression of CD64","volume":"91","author":"Fadlon E","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1182\/blood.V82.6.1891.1891","article-title":"\u03b14\u03b21\u2010integrin expression on sickle reticulocytes: vascular cell adhesion molecule\u20101\u2010dependent binding to endothelium","volume":"82","author":"Swerlick RA","year":"1993","journal-title":"Blood"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.1.268.bloodjournal851268"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.16.7430"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237096"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.2.458"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.9.3082"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199911000-00039"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2004.04.010"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1843.2006.00900.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1843.2006.00900.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T01:45:15Z","timestamp":1697247915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1843.2006.00900.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,3]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1440-1843.2006.00900.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1843.2006.00900.x","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,3]]}}}