{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:31:22Z","timestamp":1791106282137,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,19]],"date-time":"2006-12-19T00:00:00Z","timestamp":1166486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> The present study was performed to examine the occurrence of dynamic hyperinflation following hyperventilation in COPD patients and former smokers without COPD, and the efficacy of short\u2010acting anticholinergic agents (SAAC) and \u03b2<jats:sub>2<\/jats:sub>\u2010agonists (SABA) for lung hyperinflation following metronome\u2010paced hyperventilation in COPD.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Fifty\u2010nine patients with COPD, 20 ex\u2010smokers without COPD and 20 healthy subjects who had never smoked were examined for dynamic hyperinflation by metronome\u2010paced hyperventilation with respiratory rate increasing from 20 to 30 and 40 tidal breaths\/min. Dynamic hyperinflation was evaluated as the decrease in inspiratory capacity (IC) following hyperventilation, and the effects of SAAC and SABA on dynamic hyperinflation were assessed.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> COPD patients showed a significant increase in end\u2010expiratory lung volume and a decrease in IC following hyperventilation, and ex\u2010smokers without COPD also showed mild but significant dynamic hyperinflation. Multiple stepwise linear regression analysis revealed that the carbon monoxide transfer coefficient (DLco\/V<jats:sub>A<\/jats:sub>) and RV\/TLC were significant and independent determinants of dynamic hyperinflation in COPD. Treatment with SAAC and SABA significantly increased IC at each respiratory rate, independently of the increases in FEV<jats:sub>1<\/jats:sub>. Furthermore, SABA significantly inhibited the decrease in IC due to hyperventilation.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> These findings suggest that lung hyperinflation following hyperventilation may be a useful method for detecting dynamic hyperinflation observed not only in patients with COPD but also in ex\u2010smokers without COPD, and both SAAC and SABA are effective in reducing dynamic hyperinflation in COPD.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2006.00963.x","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T14:45:27Z","timestamp":1166625927000},"page":"93-99","source":"Crossref","is-referenced-by-count":28,"title":["Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD"],"prefix":"10.1111","volume":"12","author":[{"given":"Keisaku","family":"FUJIMOTO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"YOSHIIKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"YASUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"KITAGUCHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"URUSHIHATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"KUBO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"HONDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.5.1351"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.5.2012122"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2201003"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16b14.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.3.8630581"},{"key":"e_1_2_6_7_2","first-page":"33","article-title":"Chest wall mechanics during exercise in patients with severe chronic airflow obstruction","volume":"12","author":"Dodd DS","year":"1984","journal-title":"Am. 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