{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:13:52Z","timestamp":1769238832447,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,19]],"date-time":"2006-12-19T00:00:00Z","timestamp":1166486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> QuantiFERON<jats:sup>\u00ae<\/jats:sup>\u2010TB Gold (QFT\u2010G) was employed in a contact investigation in a high school to evaluate its performance in adolescents.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Students of the same school grade as the index case were screened with tuberculin skin test (TST) and CXR examination as an initial contact investigation. QFT\u2010G was performed for students demonstrating a positive TST (erythema larger than 30\u2003mm).<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Of 349 students whose TST was completed, 95 had positive TST responses, although the distribution of TST responses was similar for both high and low exposure groups. In contrast, only four of the 88 TST\u2010positive students tested with QFT\u2010G were positive by this test, and three of these were from the high exposure group. Chemoprophylaxis was provided to only those four QFT\u2010G\u2010positive students. Follow up of the 91 students who were TST\u2010positive, but QFT\u2010G\u2010negative (or not tested), for more than 3.5\u2003years revealed that none have developed active tuberculosis.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> QFT\u2010G appears more specific than TST as contacts with positive TST and negative QFT\u2010G responses were not offered prophylaxis and none developed tuberculosis during 3.5\u2003years of follow up. The replacement of TST with QFT\u2010G, or perhaps combined use of TST and QFT\u2010G, may be more useful in diagnosing true infection and thus reducing the number of subjects indicated for chemoprophylaxis.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2006.01000.x","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T14:45:27Z","timestamp":1166625927000},"page":"88-92","source":"Crossref","is-referenced-by-count":44,"title":["Use of QuantiFERON<sup>\u00ae<\/sup>\u2010TB Gold to investigate tuberculosis contacts in a high school"],"prefix":"10.1111","volume":"12","author":[{"given":"Kazue","family":"HIGUCHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"HARADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"MORI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukie","family":"SEKIYA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,19]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Statistics of Tuberculosis 2005.","author":"Ministry of Health, Labor and Welfare","year":"2005"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.6.968"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02742-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-179OC"},{"key":"e_1_2_6_6_2","first-page":"637","article-title":"Usefulness of a novel diagnostic method of tuberculosis infection, QuantiFERON\u00aeTB\u20102G, in an outbreak of tuberculosis","volume":"79","author":"Harada N","year":"2004","journal-title":"Kekkaku"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-232OC"},{"key":"e_1_2_6_8_2","first-page":"527","article-title":"Usefulness of QuantiFERON TB\u20102G in contact investigation of a tuberculosis outbreak in a University","volume":"80","author":"Funayama K","year":"2005","journal-title":"Kekkaku"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/504358"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2756"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2746"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-77"},{"key":"e_1_2_6_13_2","first-page":"563","article-title":"Further studies on the potency of purified protein derivatives of tuberculin (PPD\u2010s). 1st Report. 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