{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:38:47Z","timestamp":1792611527454,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T00:00:00Z","timestamp":1180137600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> The prognosis in patients with pulmonary tuberculosis and acute respiratory failure requiring mechanical ventilation is believed to be poor. The aim of this study was to identify factors contributing to in\u2010hospital mortality in these patients.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> The medical records of 32 patients with active pulmonary tuberculosis as a primary cause of acute respiratory failure requiring mechanical ventilation in the medical intensive care unit (ICU) of a tertiary referral hospital over a 10\u2010year period were reviewed retrospectively, and predictors of mortality were assessed.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> The patients\u2019 median age was 69\u2003years (range 25\u201388\u2003years). The median length of intensive care unit stay was 11\u2003days (range 2\u201388\u2003days), and the median duration of mechanical ventilation was 9\u2003days (range 2\u201386\u2003days). Overall in\u2010hospital mortality was 59% (19\/32). Independent predictive factors of in\u2010hospital mortality included tuberculous\u2010destroyed lungs (hazard ratio 6.61, 95% CI: 1.21\u201336.04, <jats:italic>P<\/jats:italic>\u2003= 0.029), Acute Physiology and Chronic Health Evaluation II scores \u226520 (hazard ratio 4.90, 95% CI: 1.43\u201316.80, <jats:italic>P<\/jats:italic>\u2003=\u20030.012) and sepsis (hazard ratio 5.84, 95% CI: 1.63\u201320.95, <jats:italic>P<\/jats:italic>\u2003=\u20030.007).<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Acute respiratory failure caused by pulmonary tuberculosis necessitating mechanical ventilation has a high mortality rate and poor prognosis, particularly in patients with tuberculous\u2010destroyed lungs, high Acute Physiology and Chronic Health Evaluation II scores and sepsis.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2006.01007.x","type":"journal-article","created":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T22:06:15Z","timestamp":1180217175000},"page":"406-411","source":"Crossref","is-referenced-by-count":43,"title":["Prognostic factors in pulmonary tuberculosis requiring mechanical ventilation for acute respiratory failure"],"prefix":"10.1111","volume":"12","author":[{"given":"Yon Ju","family":"RYU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Jung","family":"KOH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hae","family":"KANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gee Young","family":"SUH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Pyo","family":"CHUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojoong","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O Jung","family":"KWON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.72.5.605"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198703000-00008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/151.3_Pt_1.867"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00038703"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198711000-00005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.148.5.1103"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.5.1244"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340000849"},{"key":"e_1_2_6_10_2","first-page":"563","article-title":"Features of severe pneumonia in patients with undiagnosed pulmonary tuberculosis in an intensive care unit","volume":"102","author":"Hui C","year":"2003","journal-title":"J. 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