{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:20:20Z","timestamp":1726435220966},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T00:00:00Z","timestamp":1199836800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> The prevalence of multidrug\u2010resistant tuberculosis (MDR\u2010TB) has increased substantially in the past 20\u2003years, however, there are no data specific to Iran. This study investigated patients suspected to have MDR\u2010TB, attending the TB referral hospital in Iran.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> All patients suspected of having MDR\u2010TB on hospital admission in the period 2003\u20132005 were included in this study. Sputum from all patients was tested for smear and culture, and drug sensitivity testing was performed using the proportion method. Patients were categorized into three groups based on their history of medical treatment. Group I consisted of patients with CAT I regimen failure; Group II consisted of patients with a history of CAT II regimen failure and Group III comprised patients with a history of more than two courses of irregular CAT I anti\u2010TB regimen.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> There were 105 patients recruited; 32 in Group I, 53 in Group II and 20 in Group III. There were no significant differences between the three groups in their resistance to first\u2010line anti\u2010TB drugs. Fifty\u2010five patients were diagnosed with MDR\u2010TB. The prevalence of MDR\u2010TB was 56% (18 cases) in group I, 49% (26 cases) in group II and 55% (11 cases) in group III. No significant difference in the pattern of drug resistance was observed between the three groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> The prevalence of MDR\u2010TB was high in this study. The lack of response of MDR\u2010TB patients to CAT II treatment indicates that antibiotic sensitivity testing is essential in patients with CAT I treatment failure.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2007.01201.x","type":"journal-article","created":{"date-parts":[[2010,9,21]],"date-time":"2010-09-21T11:12:49Z","timestamp":1285067569000},"page":"108-111","source":"Crossref","is-referenced-by-count":6,"title":["Representative drug susceptibility patterns for guiding design of re\u2010treatment regimens for multidrug\u2010resistant tuberculosis in Iran"],"prefix":"10.1111","volume":"13","author":[{"given":"Payam","family":"TABARSI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azar","family":"NOORAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"MIRSAEIDI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"AMIRI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvaneh","family":"BAGHAEI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"FARNIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"KAZEMPOUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"HEIDARNAZHAD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narges","family":"ALIPANAH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davood","family":"MANSOURI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad R.","family":"MASJEDI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104263441706"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1412"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309093291108"},{"key":"e_1_2_5_5_2","first-page":"885","article-title":"Determinants of drug resistant tuberculosis: analysis of 11 countries","volume":"5","author":"Espinal MA","year":"2001","journal-title":"Int. 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