{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:35:15Z","timestamp":1785180915699,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> Standard bronchoscopic techniques (transbronchial lung biopsy and endobronchial biopsy) provide a diagnosis in 70% of patients with pulmonary sarcoidosis. Previous data suggest that endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) has a high sensitivity in patients with sarcoidosis. The feasibility and utility of combining EBUS\u2010TBNA with standard bronchoscopic techniques is unknown. The aim of this study was to evaluate the feasibility, safety and efficacy of combined EBUS\u2010TBNA and standard bronchoscopic techniques in patients with suspected sarcoidosis and enlarged mediastinal or hilar lymphadenopathy.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Forty consecutive patients with suspected pulmonary sarcoidosis and enlarged mediastinal or hilar lymph nodes (radiographical stage I and stage II) underwent EBUS\u2010TBNA followed by transbronchial biopsies and endobronchial biopsies under conscious sedation.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Thirty\u2010nine out of 40 patients successfully underwent combined EBUS\u2010TBNA and standard bronchoscopy. Twenty\u2010seven patients were diagnosed with sarcoidosis, eight had tuberculosis, two had reactive lymphadenopathy, two had lymphoma and one had metastatic adenocarcinoma. In patients with sarcoidosis, the sensitivity of EBUS\u2010TBNA for detection of non\u2010caseating granulomas was 85%, compared with a sensitivity of 35% for standard bronchoscopic techniques (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). The diagnostic yield of combined EBUS\u2010TBNA and bronchoscopy was 93% (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001).<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> Combination of EBUS\u2010TBNA with standard bronchoscopic techniques is safe and feasible, and optimizes the diagnostic yield in patients with pulmonary sarcoidosis and enlarged intrathoracic lymphadenopathy.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2011.01933.x","type":"journal-article","created":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T11:35:42Z","timestamp":1295955342000},"page":"467-472","source":"Crossref","is-referenced-by-count":99,"title":["Combination of endobronchial ultrasound\u2010guided transbronchial needle aspiration with standard bronchoscopic techniques for the diagnosis of stage I and stage II pulmonary sarcoidosis"],"prefix":"10.1111","volume":"16","author":[{"given":"NEAL","family":"NAVANI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELEN L.","family":"BOOTH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GABRIJELA","family":"KOCJAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARY","family":"FALZON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARRIGO","family":"CAPITANIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAMES M.","family":"BROWN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOANNA C.","family":"PORTER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAM M.","family":"JANES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071714"},{"key":"e_1_2_6_3_2","first-page":"217","article-title":"Combining transbronchial aspiration with endobronchial and transbronchial biopsy in sarcoidosis","volume":"54","author":"Bilaceroglu S","year":"1999","journal-title":"Monaldi Arch. Chest Dis."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.3.881"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2768"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028706"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2007.01145.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0998"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.07.013"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.031"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.6.1718"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.047829"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.105031"},{"issue":"5","key":"e_1_2_6_14_2","first-page":"v1\u201058","article-title":"Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society","volume":"63","author":"Bradley B","year":"2008","journal-title":"Thorax"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.1.147"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.11.011"},{"key":"e_1_2_6_17_2","first-page":"147","article-title":"Transbronchial needle aspiration improves the diagnostic yield of bronchoscopy in sarcoidosis","volume":"21","author":"Trisolini R","year":"2004","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00111509"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1843.2011.01933.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1843.2011.01933.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T12:54:11Z","timestamp":1697288051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1843.2011.01933.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,30]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1111\/j.1440-1843.2011.01933.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1843.2011.01933.x","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,30]]}}}