{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:20:36Z","timestamp":1781716836501,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T00:00:00Z","timestamp":1303689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> Extracellular matrix metalloproteinase inducer (EMMPRIN or CD147) induces the production of matrix metalloproteinases (MMP) such as MMP\u20109, which plays an important role in COPD. We determined its cellular origin and role in MMP\u20109 production in COPD.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Bronchial biopsies, alveolar macrophages (AM) and blood monocytes (BM) from patients with COPD, healthy smokers and non\u2010smokers, and bronchial epithelial cells (EC) from surgically resected airways from patients with COPD were stimulated with LPS or CRP in the presence and absence of an anti\u2010EMMPRIN blocking antibody. EMMPRIN in BAL, plasma, conditioned media and cell lysates was quantified and immunohistochemical localization of EMMPRIN was determined in bronchial biopsies. MMP\u20109 activity and mRNA was also determined.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> EMMPRIN levels in BAL fluid were higher in patients with COPD compared with non\u2010smokers and smokers. There was greater EMMPRIN expression in EC from patients with COPD compared with smokers and non\u2010smokers. EC secreted and expressed more EMMPRIN protein than BM and AM. Blocking EMMPRIN decreased MMP\u20109 activity in supernatant of EC, but not in those from AM and BM, and decreased MMP\u20109 mRNA expression in EC.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> The increased EMMPRIN expression in COPD is reflected by an increased release from bronchial EC, which are one of the main source of EMMPRIN. EMMPRIN regulates MMP\u20109 expression in COPD.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2011.01960.x","type":"journal-article","created":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T23:38:04Z","timestamp":1299022684000},"page":"705-712","source":"Crossref","is-referenced-by-count":33,"title":["EMMPRIN (CD147) regulation of MMP\u20109 in bronchial epithelial cells in COPD"],"prefix":"10.1111","volume":"16","author":[{"given":"STEPHANE","family":"JOUNEAU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NADIA","family":"KHORASANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICIA","family":"DE SOUZA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICIA","family":"MACEDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIE","family":"ZHU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PANKAJ K.","family":"BHAVSAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KIAN F.","family":"CHUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00018908"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.3.684"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.10.022"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.26.5.4685"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9910097"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00020.2002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00481.2007"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.46.29174"},{"issue":"2","key":"e_1_2_6_10_2","first-page":"434","article-title":"The human tumor cell\u2010derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily","volume":"55","author":"Biswas C","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0601"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.25.6.4558f"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64660-3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<347::AID-IJC9>3.0.CO;2-#"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-103OC"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/01902140600710512"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2007.08.014"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61383-X"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.059808"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.06.015"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092506"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.70.267"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.03.006"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/14622200701488392"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.09.023"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207070"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205702"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000112826"},{"key":"e_1_2_6_29_2","first-page":"693","article-title":"Increased expression of matrix metalloproteinase\u20102 (MMP\u20102) predicts tumour recurrence and unfavourable outcome in non\u2010small cell lung cancer","volume":"23","author":"Leinonen T","year":"2008","journal-title":"Histol. 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