{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:03:39Z","timestamp":1772759019169,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T00:00:00Z","timestamp":1311552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> Community\u2010associated methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (CA\u2010MRSA) strains are primarily associated with skin and soft tissue infections; however, they are increasingly causing more invasive infections including severe community\u2010acquired pneumonia. The objective of this study was to describe the clinico\u2010pathological characteristics of community\u2010acquired MRSA pneumonia.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> A retrospective analysis of case records from January 2002 to August 2008 was performed on patients admitted with community\u2010acquired MRSA pneumonia to two large teaching hospitals.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Sixteen patients with community\u2010acquired MRSA pneumonia were identified. Their age ranged from 11\u2003months to 86\u2003years (median age; 30\u2003years). Duration of symptoms before hospital presentation ranged from one to 21\u2003days. Most patients had productive cough, fever and dyspnoea. The most common radiological presentation included multilobar consolidation (8\/16), necrotizing consolidation (7\/16) and empyema (5\/16).<\/jats:p><jats:p>Seven patients required intensive care support; four required ionotropic support and five required mechanical ventilation for a mean duration of 53\u2003h and 6.6\u2003days, respectively. Six patients underwent surgery (VATS or open thoracotomy). There was a mean delay of approximately 69\u2003h (range; 18\u2003h to 11\u2003days) after presentation before appropriate MRSA antimicrobial treatment was initiated. Three patients died of complications from pneumonia, all within 72\u2003h of presentation. Among survivors, the average length of hospital stay was 23.8\u2003days (range; 10\u201349\u2003days). Majority of survivors were left with mild residual radiological changes.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> Community\u2010acquired MRSA pneumonia is increasing and should be suspected in patients with severe community\u2010acquired pneumonia. There was a delay in initiation of appropriate antimicrobial treatment that could have lead to increased morbidity.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2011.01965.x","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T07:18:24Z","timestamp":1299568704000},"page":"926-931","source":"Crossref","is-referenced-by-count":20,"title":["Community\u2010acquired methicillin\u2010resistant <i>Staphylococcus aureus<\/i> pneumonia: A clinical audit"],"prefix":"10.1111","volume":"16","author":[{"given":"RAJESH","family":"THOMAS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"FERGUSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEOFFREY","family":"COOMBS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G","family":"GIBSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.14.4.385"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/533594"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.159.10.980"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.22.2976"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042859"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/427148"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1102.040782"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/345436"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1206.051141"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/591803"},{"key":"e_1_2_6_12_2","first-page":"1010","article-title":"Fatal bacteraemic pneumonia due to community\u2010acquired methicillin\u2010resistant staphylococcus aureus","volume":"47","author":"Yang HL","year":"2006","journal-title":"Singapore Med. 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