{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:39:37Z","timestamp":1782229177103,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T00:00:00Z","timestamp":1309219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> Studies in respiratory diseases other than chronic obstructive pulmonary disease suggest potentially differing responses to medications among patients from different regions. We report a subgroup analysis of patients recruited to Asian centres from a previously reported 4\u2010year COPD trial.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Subgroup analysis from a randomized, double\u2010blinded, placebo\u2010controlled trial of tiotropium 18\u2003\u00b5g daily in COPD. Primary end\u2010point was rate of decline in FEV<jats:sub>1<\/jats:sub>. Secondary end\u2010points included spirometry at individual time points, health\u2010related quality of life (St George's Respiratory Questionnaire), exacerbations and mortality.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Of 5992 patients, 362 were from Asian centres (100 from Japan). Mean age 66\u2003years, 95% men, 13% current smokers, BMI: 21\u2003kg\/m<jats:sup>2<\/jats:sup>; post\u2010bronchodilator FEV<jats:sub>1<\/jats:sub>: 44% predicted; St George's Respiratory Questionnaire total score: 44 units. No treatment effect was observed for rate of decline in FEV<jats:sub>1<\/jats:sub> although annual decline was less in Asian patients. Morning pre\u2010bronchodilator FEV<jats:sub>1<\/jats:sub> and forced vital capacity improved in Asian patients (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Tiotropium reduced number of exacerbations (rate ratio (95% confidence interval (CI)): 0.73 (0.57\u20130.94)). Hazard ratios (95%CI) for exacerbations and hospitalized exacerbations (tiotropium\/control) were 0.81 (0.62\u20131.05) and 0.85 (0.61\u20131.19), respectively. St George's Respiratory Questionnaire total score improved by 1.5\u20136.1 units (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05 for months 18, 24, 30 and 36) with tiotropium. Fatal events occurred in 34 tiotropium (18.5%) and 42 control (23.6%) patients.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> In COPD patients from Asia, tiotropium improves lung function, improves health\u2010related quality of life and reduces exacerbations over 4\u2003years of treatment.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2011.01982.x","type":"journal-article","created":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T12:18:15Z","timestamp":1304425095000},"page":"825-835","source":"Crossref","is-referenced-by-count":37,"title":["Efficacy of tiotropium in COPD patients from Asia: A subgroup analysis from the UPLIFT trial"],"prefix":"10.1111","volume":"16","author":[{"given":"YOSHINOSUKE","family":"FUKUCHI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LENORA","family":"FERNANDEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAN\u2010PIN","family":"KUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AZIAH","family":"MAHAYIDDIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BARTOLOME","family":"CELLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARC","family":"DECRAMER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEVEN","family":"KESTEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DACHENG","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DONALD","family":"TASHKIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,28]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Global Initiative for Chronic Obstructive Lung Disease.Global strategy for the diagnosis management and prevention of chronic obstructive pulmonary disease. 2009 update. [Accessed 1 Dec 2009.] Available from URL:http:\/\/www.goldcopd.com"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01415.x"},{"key":"e_1_2_6_4_2","first-page":"713","article-title":"Worldwide burden of COPD in high\u2010 and low\u2010income countries. Part III. Asia\u2010Pacific studies","volume":"12","author":"Ko FW","year":"2008","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2004.00637.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1131"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2005.00692.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805800"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0876OC"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61298-8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00082909"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.03.033"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00127809"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200026934"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753465807081747"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200409-1286OC"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/02770900701554441"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60055-5"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1.15"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2004.00611.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00930.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60869-7"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2004.00573.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00897.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.09.012"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1843.2011.01982.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1843.2011.01982.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T10:37:15Z","timestamp":1697279835000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1843.2011.01982.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,28]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1111\/j.1440-1843.2011.01982.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1843.2011.01982.x","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,28]]}}}