{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:15:23Z","timestamp":1788383723823,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> COPD and bronchial asthma are chronic airway diseases with a different pathogenesis. Comparisons of differences in airway calibre by bronchial generation between these diseases and their importance to pulmonary function have not been fully studied. We investigated airway calibre and wall thickness in relation to pulmonary function in patients with asthma, COPD, asthma plus emphysema and normal subjects using CT.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Sixty\u2010three asthmatic patients, 46 COPD, 23 patients with asthma plus emphysema and 61 control subjects were studied cross\u2010sectionally. We used a software with curved multiplanar reconstruction to measure airway dimensions from 3rd\u2010 to 6th\u2010generation bronchi of the right lower posterior bronchus.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Patients with COPD had increased wall thickness, but the airway was not narrow from the 3rd\u2010(subsegmental) to 6th\u2010generation bronchi. Mean bronchial inner diameter (Di) of 3rd\u2010 to 6th\u2010generation bronchi in patients with asthma or asthma plus emphysema was smaller than that of COPD patients and normal subjects. Airway luminal area (Ai) of 5th\u2010generation bronchi most closely correlated with pulmonary function in patients with stable asthma. Although Di was similar in patients with asthma and asthma plus emphysema, the Ai of 6th\u2010generation bronchi correlated significantly with pulmonary function in patients with asthma plus emphysema.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> Airway calibre in asthma may be smaller than in COPD. Airflow limitations correlated more closely with peripheral Ai in patients with asthma plus emphysema than in patients with asthma alone.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2011.02052.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:44:48Z","timestamp":1314837888000},"page":"79-86","source":"Crossref","is-referenced-by-count":24,"title":["Airway dimensions and pulmonary function in chronic obstructive pulmonary disease and bronchial asthma"],"prefix":"10.1111","volume":"17","author":[{"given":"KAZUYOSHI","family":"KURASHIMA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOSHIKO","family":"HOSHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NOBORU","family":"TAKAYANAGI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOTARO","family":"TAKAKU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NAHO","family":"KAGIYAMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHIE","family":"OHTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAKI","family":"FUJIMURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUTAKA","family":"SUGITA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,21]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease, Updated 2008","author":"Global Initiative for Chronic Obstructive Lung Disease (GOLD)","year":"2008"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.1.169"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633722"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.2010066"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.3.1016"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032158"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200601-037OC"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2491071650"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.029"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2005.10.007"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200504040-00001"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14614039"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9909044"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00007105"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1117\/12.463615"},{"key":"e_1_2_5_17_2","volume-title":"General Rule for Clinical and Pathological Record of Lung Cancer","author":"The Japan Lung Cancer Society","year":"1999"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663792"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1968.24.3.373"},{"key":"e_1_2_5_20_2","first-page":"527","article-title":"Airway morphology and its consequences","volume":"8","author":"Cumming G","year":"1972","journal-title":"Bull. 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