{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:05:23Z","timestamp":1769691923860,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T00:00:00Z","timestamp":1327363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> We hypothesized that the prevalence of allergic disorders, characterized by the release of type 2 cytokines (IL\u20104, IL\u20105, IL\u201010), would be lower in sarcoidosis in which there is a dominant type 1 immune response (IL\u20102, interferon\u2010gamma). The objective was to measure the prevalence of atopy and self\u2010reported asthma in patients with sarcoidosis.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Sarcoidosis patients (<jats:italic>n<\/jats:italic>\u2003=\u2003136, 72\u2003M, age range 22\u201375), recruited in the outpatient setting, completed a modified European Community Respiratory Health Survey. 123 of these patients provided blood for allergy testing.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> For the cohort as a whole the self\u2010reported prevalence of asthma ever (21.5%) and asthma attack in the last 12\u2003months (7.5%), was high as was wheezing (42.1%), breathlessness with wheeze (22.3%) and use of an asthma medication (13.1%). The prevalence of atopy was 34%. These data are not different from the previously reported prevalence of asthma and atopy in New Zealand.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> The same prevalence of asthma symptoms and atopy as in the normal population suggests that the immune system is not skewed away from mounting T helper type 2 immune responses in sarcoidosis.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2011.02066.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T13:40:17Z","timestamp":1317130817000},"page":"285-290","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence of asthma and atopy in sarcoidosis"],"prefix":"10.1111","volume":"17","author":[{"given":"MARGARET","family":"WILSHER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAEWYN","family":"HOPKINS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IRENE","family":"ZENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEGAN","family":"CORNERE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"DOUGLAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12888-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198304073081401"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201303260504"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0118"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91617-7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5296.77"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.6.454"},{"key":"e_1_2_6_9_2","first-page":"417","article-title":"The self reported prevalence of asthma symptoms amongst adult New Zealanders","volume":"107","author":"Crane J","year":"1994","journal-title":"N. 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