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Injury to the lung is often reported as part of multi\u2010organ failure in victims of accidental exposures. Doses of radiation &gt;8 Gray to the chest can induce pneumonitis with right ventricular hypertrophy starting after \u223c2\u2003months. Higher doses may be followed by pulmonary fibrosis that presents months to years after exposure. Though the exact mechanisms of radiation lung damage are not known, experimental animal models have been widely used to study this injury. Rodent models for pneumonitis and fibrosis exhibit vascular, parenchymal and pleural injuries to the lung. Inflammation is a part of the injuries suggesting involvement of the immune system. Researchers worldwide have tested a number of interventions to prevent or mitigate radiation lung injury. One of the first and most successful class of mitigators are inhibitors of angiotensin\u2010converting enzyme (ACE), an enzyme that is abundant in the lung. These results offer hope that lung injury from radiation accidents may be mitigated, since the ACE inhibitor captopril was effective when started up to 1\u2003week after irradiation.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2011.02092.x","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T15:14:32Z","timestamp":1319469272000},"page":"66-71","source":"Crossref","is-referenced-by-count":94,"title":["Radiation damage to the lung: Mitigation by angiotensin\u2010converting enzyme (ACE) inhibitors"],"prefix":"10.1111","volume":"17","author":[{"given":"MEETHA","family":"MEDHORA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FENG","family":"GAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELIZABETH R.","family":"JACOBS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN E.","family":"MOULDER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.03.058"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/27824773"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/84574102"},{"key":"e_1_2_7_5_2","unstructured":"International Atomic Energy Agency.The radiological accident in Goiania.DelvesD FhttonS(eds) [Accessed 7 November 2011.] Available from URL:http:\/\/www\u2010pub.iaea.org\/mtcd\/publications\/pdf\/pub815_web.pdf."},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/38625621"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/90331492"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/39031657"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/51028846"},{"key":"e_1_2_7_10_2","unstructured":"AramratanaM BoonnakS BoonpadhanapongTet\u2003al.International Atomic Energy Agency.The radiological accident in Samut Prakarn. 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