{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:40:19Z","timestamp":1774482019796,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T00:00:00Z","timestamp":1340668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background and objective:\u2003<\/jats:bold>\n                    Loop gain is an engineering term that predicts the stability of a feedback control system, such as the control of breathing. Based on earlier studies at lower altitudes, it was hypothesized that acclimatization to high altitude would lead to a reduction in loop gain and thus central sleep apnoea (CSA) severity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2003<\/jats:bold>\n                    This study used exposure to very high altitude to induce CSA in healthy subjects to investigate the effect of partial acclimatization on loop gain and CSA severity. Measurements were made on 12 subjects (age 30\u2003\u00b1\u200310 years, body mass index 22.8\u2003\u00b1\u20031.9, eight males, four females) at an altitude of 5050\u2003m over a 2\u2010week period upon initial arrival (days 2\u20134) and following partial acclimatization (days 12\u201314). Sleep was studied by full polysomnography, and resting arterial blood gases were measured. Loop gain was measured by the \u2018duty cycle\u2019 method (duration of hyperpnoea\/cycle length).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2003<\/jats:bold>\n                    Partial acclimatization to high\u2010altitude exposure was associated with both an increase in loop gain (duty cycle fell from 0.60\u2003\u00b1\u20030.05 to 0.55\u2003\u00b1\u20030.06 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.03)) and severity of CSA (apnoea\u2010hypopnoea index increased from 76.8\u2003\u00b1\u200348.8 to 115.9\u2003\u00b1\u200320.2 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.01)), while partial arterial carbon dioxide concentration fell from 29\u2003\u00b1\u20033 to 26\u2003\u00b1\u20032 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.01).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2003<\/jats:bold>\n                    Contrary to the results at lower altitudes, at high\u2010altitude loop gain and severity of CSA increased.\n                  <\/jats:p>","DOI":"10.1111\/j.1440-1843.2012.02170.x","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T04:07:24Z","timestamp":1332216444000},"page":"835-840","source":"Crossref","is-referenced-by-count":25,"title":["The effect of partial acclimatization to high altitude on loop gain and central sleep apnoea severity"],"prefix":"10.1111","volume":"17","author":[{"given":"GARETH","family":"ANDREWS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHILIP 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