{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:26:36Z","timestamp":1790666796171,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:00:00Z","timestamp":1351123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> Although it has been reported that pulmonary hypertension is more frequent in patients with obesity\u2010hypoventilation syndrome than in patients with \u2018pure\u2019 obstructive sleep apnoea syndrome, little is known about the haemodynamic repercussions of this entity. The aim was to describe the haemodynamic status, as assessed by echocardiography and 6\u2010min walk test (6MWT), of patients with a newly diagnosed, most severe form of obesity\u2010hypoventilation syndrome, and to evaluate the impact of non\u2010invasive ventilation in these patients.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> A prospective, descriptive, and single\u2010centre follow\u2010up study was conducted. At baseline, patients underwent echocardiography, spirometry, static lung volume measurement, 6MWT, overnight pulse\u2010oximetry and polygraphic recording. Changes in echocardiography and 6MWT were assessed after 6 months of non\u2010invasive ventilation. Right ventricular overload was defined on the basis of right ventricular dilatation, hypokinesis, paradoxical septal motion and\/or pulmonary hypertension.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Thirty patients (20 women; mean age 69\u2003\u00b1\u200311) were tested. The percentage of patients with right ventricular overload did not change significantly after non\u2010invasive ventilation (43.3\u201341.6%; <jats:italic>P<\/jats:italic>\u2003=\u20030.24). In patients with right ventricular overload at diagnosis, pulmonary artery systolic pressure decreased significantly at six months (58\u2003\u00b1\u200311 to 44\u2003\u00b1\u200312\u2003mm\u2003Hg; <jats:italic>P<\/jats:italic>\u2003=\u20030.014), and mean distance on 6MWT increased from 350\u2003\u00b1\u2003110 to 426\u2003\u00b1\u200378\u2003m (<jats:italic>P<\/jats:italic>\u2003=\u20030.006), without significant changes in body mass index.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> Right ventricular overload is a frequent finding in patients with the most severe form of obesity\u2010hypoventilation syndrome. Treatment with non\u2010invasive ventilation is associated with a decrease in pulmonary artery systolic pressure at six months and an increase in the distance covered during the 6MWT.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2012.02252.x","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T09:43:07Z","timestamp":1345196587000},"page":"1269-1274","source":"Crossref","is-referenced-by-count":71,"title":["Haemodynamic effects of non\u2010invasive ventilation in patients with obesity\u2010hypoventilation syndrome"],"prefix":"10.1111","volume":"17","author":[{"given":"OLALLA","family":"CASTRO\u2010A\u00d1\u00d3N","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAFAEL","family":"GOLPE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUIS A.","family":"P\u00c9REZ\u2010DE\u2010LLANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAR\u00cdA JES\u00daS","family":"L\u00d3PEZ GONZ\u00c1LEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EDGAR J.","family":"ESCALONA VELASQUEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RUTH","family":"P\u00c9REZ FERN\u00c1NDEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANA","family":"TESTA FERN\u00c1NDEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARTURO","family":"GONZ\u00c1LEZ QUINTELA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.03.042"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.08.022"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.587"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2334"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.11.934"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9805086"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.2010092"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.2.369"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-010-0360-5"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.587"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1183\/09041950.005s1693","article-title":"Lung volumes and forced expiratory flows","volume":"6","author":"Quanjer PH","year":"1993","journal-title":"Eur. 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