{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:02:17Z","timestamp":1793887337642,"version":"4.8.0"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adult obstructive sleep apnoea (OSA) is associated with cognitive dysfunction. While many review articles have attempted to summarize the evidence for this association, it remains difficult to determine which domains of cognition are affected by OSA. This is because of marked differences in the nature of these reviews (e.g. many are unsystematic) and the many different tasks and domains assessed. This paper addresses this issue by comparing the results of only systematic reviews or meta\u2010analyses assessing the effects of OSA on cognition, the relationship between OSA severity and cognition, and\/or the effects of treatment on cognition in OSA. Electronic databases and hand\u2010searching were undertaken to select reviews that reported on these areas. We found 33 reviews; five reviews met predetermined, stringent selection criteria. The majority of reviews supported deficits in attention\/vigilance, delayed long\u2010term visual and verbal memory, visuospatial\/constructional abilities, and executive function in individuals with OSA. There is also general agreement that language ability and psychomotor function are unaffected by OSA. Data are equivocal for the effects of OSA on working memory, short\u2010term memory and global cognitive functioning. Attention\/vigilance dysfunction appears to be associated with sleep fragmentation and global cognitive function with hypoxaemia. Continuous positive airway pressure treatment of OSA appears to improve executive dysfunction, delayed long\u2010term verbal and visual memory, attention\/vigilance and global cognitive functioning. In order to improve our understanding of cognitive dysfunction in OSA, future research should pay particular attention to participant characteristics, measures of disease severity and choice of neuropsychological tests.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2012.02255.x","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T03:45:06Z","timestamp":1345693506000},"page":"61-70","source":"Crossref","is-referenced-by-count":439,"title":["Neurocognitive function in obstructive sleep apnoea: A meta\u2010review"],"prefix":"10.1111","volume":"18","author":[{"given":"ROMOLA S.","family":"BUCKS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHELLE","family":"OLAITHE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER","family":"EASTWOOD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,26]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"113","volume-title":"Fundamentals of Sleep Technology","author":"Guilleminault C","year":"2007"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/20.9.705"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.9.998"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.02069.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.1996.d01-60.x"},{"issue":"4","key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"424","DOI":"10.5664\/jcsm.26658","article-title":"Correlates of depressive symptoms in patients with obstructive sleep apnea","volume":"2","author":"McCall WV","year":"2006","journal-title":"J. Clin. Sleep Med."},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900018356"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/09540260500104508"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688639108405110"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.90.5.686"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.24.1.93.973"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2002.00289.x"},{"key":"e_1_2_7_14_2","unstructured":"SuttonAM.Executive functioning in the presence of sleep disordered breathing. Dissertation Abstracts International: Section B: The Sciences and Engineering.2008; 69(1\u2010B): 701."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2004.01.001"},{"issue":"4","key":"e_1_2_7_16_2","first-page":"685","article-title":"Executive function in sleep apnea: controlling for attentional capacity in assessing executive attention","volume":"27","author":"Verstraeten E","year":"2004","journal-title":"Sleep"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2000.00225.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5248.512"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(98)00141-9"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-007-0012-8"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2008.07.002"},{"key":"e_1_2_7_22_2","volume-title":"Why We Sleep","author":"Horne JA","year":"1988"},{"key":"e_1_2_7_23_2","first-page":"S3","article-title":"Blood flow and oxygen uptake in the human brain during various states of sleep and wakefulness","volume":"148","author":"Madsen PL","year":"1993","journal-title":"Acta Neurol. Scand."},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(95)00017-N"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/13803390701236116"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.03.009"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8425.2007.00257.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.11.032"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09464-3"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.3.298"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.26.1.43.23929"},{"issue":"5","key":"e_1_2_7_32_2","first-page":"234","article-title":"Obstructive sleep apnea and chronic intermittent hypoxia: a review","volume":"49","author":"Chiang AA","year":"2006","journal-title":"Chin. J. Physiol."},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2004.08.004"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617700000552"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.15.1.58"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-10-02950.1986"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.1"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200201-050OC"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000183059.52924.39"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704105134"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2004.00436.x"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1997.84.3c.1211"},{"issue":"1","key":"e_1_2_7_43_2","first-page":"36","article-title":"The influence of CPAP on the neurobehavioral performance of patients with obstructive sleep apnea hypopnea syndrome: a systematic review","volume":"102","author":"McMahon JP","year":"2003","journal-title":"WMJ"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0157"},{"issue":"1","key":"e_1_2_7_45_2","first-page":"19","article-title":"Cognitive dysfunction in sleep\u2010related breathing disorders: a meta\u2010analysis","volume":"5","author":"Fulda S","year":"2003","journal-title":"Sleep Res. Online"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00744.x"},{"key":"e_1_2_7_47_2","article-title":"Memory and obstructive sleep apnoea: a meta\u2010analysis","author":"Wallace A","year":"2012","journal-title":"Sleep"},{"key":"e_1_2_7_48_2","volume-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Strauss E","year":"2006"},{"key":"e_1_2_7_49_2","volume-title":"Neuropsychological Assessment","author":"Lezak MD","year":"2004"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.01.017"},{"key":"e_1_2_7_51_2","volume-title":"Working Memory","author":"Baddeley A","year":"1986"},{"key":"e_1_2_7_52_2","volume-title":"Learning and Memory","author":"Eichenbaum H","year":"2008"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1037\/e412952005-009"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1086\/302633"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0153"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2010-0538"},{"issue":"1","key":"e_1_2_7_57_2","first-page":"43","article-title":"Deficits of cognitive executive functions in patients with sleep apnea syndrome","volume":"18","author":"Naegele B","year":"1995","journal-title":"Sleep"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00131-2"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.02.005"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-007-0133-y"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.03.004"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.153.2.178"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200709-155MG"},{"key":"e_1_2_7_64_2","first-page":"33","volume-title":"Fundamentals of Sleep Technology","author":"S\u00f8renson E","year":"2007"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.04.009"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1805OC"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2009.11.003"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617700001326"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.9.2.231"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1843.2012.02255.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1843.2012.02255.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T12:28:36Z","timestamp":1697286516000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1843.2012.02255.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,26]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1440-1843.2012.02255.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1843.2012.02255.x","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,26]]}}}