{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:15:09Z","timestamp":1789074909666,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background and objective:\u2003<\/jats:bold>\n                    There has been increasing recognition that obstructive sleep apnoea (OSA) is associated with incident type 2 diabetes. The aim of this study was to assess the association between the severity of OSA and the risk of type 2 diabetes by performing a meta\u2010analysis of all available prospective cohort studies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2003<\/jats:bold>\n                    A search was conducted of the PubMed, EMBASE, CINAHL and ISI Web of Knowledge databases through March 2012 to identify studies linking OSA with the risk of diabetes. Only prospective cohort studies, in which the presence of OSA was confirmed by objective measurements, were included. Fixed and random effects models were used to calculate pooled relative risks (RR).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2003<\/jats:bold>\n                    This meta\u2010analysis of six prospective cohort studies including a total of 5953 participants, with follow\u2010up periods of 2.7\u201316 years, and 332 incident cases of type 2 diabetes, showed that moderate\u2010severe OSA was associated with a greater risk of diabetes (RR 1.63; 95% confidence interval (CI): 1.09\u20132.45), as compared with the absence of OSA. Sensitivity analyses yielded similar results. For subjects with mild OSA, as compared with those without OSA, the pooled RR of developing type 2 diabetes was 1.22 (95% CI: 0.91\u20131.63).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2003<\/jats:bold>\n                    This meta\u2010analysis indicates that moderate\u2010severe OSA is associated with an increased risk of type 2 diabetes, and this appears to be an independent risk factor for the development of diabetes.\n                  <\/jats:p>","DOI":"10.1111\/j.1440-1843.2012.02267.x","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T07:18:31Z","timestamp":1347952711000},"page":"140-146","source":"Crossref","is-referenced-by-count":207,"title":["Obstructive sleep apnoea and the risk of type 2 diabetes: A meta\u2010analysis of prospective cohort studies"],"prefix":"10.1111","volume":"18","author":[{"given":"XIA","family":"WANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YANPING","family":"BI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QIAN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FANG","family":"PAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60679-X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601113340207"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00587.2005"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.04.025"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.04.026"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200504-637OC"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27387"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1423OC"},{"key":"e_1_2_7_12_2","first-page":"533","article-title":"Sleep\u2010related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. 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