{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:59:41Z","timestamp":1762505981873},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background and objective:\u2003<\/jats:bold> The development of computed tomography (CT) findings usually precedes the diagnosis of pulmonary nontuberculous mycobacterial infection. The utility of specific CT scan features, although often available long before respiratory sample cultures, is not fully understood. We sought to assess associations among CT features, symptoms and microbiological disease criteria in pulmonary <jats:italic>Mycobacterium xenopi<\/jats:italic> isolation.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> We reviewed 70 consecutive immunocompetent patients with pulmonary <jats:italic>M.\u2003xenopi<\/jats:italic> isolation and classified them according to the American Thoracic Society (ATS) diagnostic criteria for disease. \u2018Definite disease\u2019 patients (<jats:italic>n<\/jats:italic>\u2003=\u200316) met modified ATS criteria. \u2018Possible disease\u2019 patients (<jats:italic>n<\/jats:italic>\u2003=\u200310) met microbiological criteria, had abnormal CT scans, but data regarding symptoms were unavailable. \u2018No disease\u2019 patients (<jats:italic>n<\/jats:italic>\u2003=\u200344) had only one positive sputum culture, or were asymptomatic or had no relevant CT findings. Two radiologists, without knowledge of the clinical or microbiological information, independently reviewed the scans.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> The mean (standard deviation) age of all patients was 63 (16) years, and 39% were women. Patients with \u2018definite disease\u2019 usually had nodules (88%) and cavities (63%), but less often bronchiectasis (50%) and tree\u2010in\u2010bud (50%). Patients with \u2018possible\u2019 or \u2018no disease\u2019, respectively, had nodules (100% or 80%), bronchiectasis (40% or 18%) or tree\u2010in\u2010bud (40% or 11%). Cavitation (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030.0001) and nodules \u22655\u2003mm (<jats:italic>P<\/jats:italic>\u2003=\u20030.0002) were associated with fulfilled microbiological criteria for disease. Bronchiectasis (<jats:italic>P<\/jats:italic>\u2003=\u20030.02) and nodules &lt;5\u2003mm (<jats:italic>P<\/jats:italic>\u2003=\u20030.002) were associated with symptoms of infection.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> Among immunocompetent patients with pulmonary <jats:italic>M.\u2003xenopi<\/jats:italic> isolation<jats:italic>,<\/jats:italic> cavitation and large nodules predict fulfilling microbiological disease criteria, while bronchiectasis and small nodules predict symptoms.<\/jats:p>","DOI":"10.1111\/j.1440-1843.2012.02277.x","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T14:15:11Z","timestamp":1349360111000},"page":"92-101","source":"Crossref","is-referenced-by-count":9,"title":["Chest computed tomography predicts microbiological burden and symptoms in pulmonary <i>Mycobacterium xenopi<\/i>"],"prefix":"10.1111","volume":"18","author":[{"given":"THEODORE K.","family":"MARRAS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"UTE","family":"WAGNETZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANCES B.","family":"JAMIESON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DEMETRIS A.","family":"PATSIOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.070797"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/15216540152845957"},{"key":"e_1_2_6_5_2","first-page":"104","article-title":"Clinical and roentgenographic features of nosocomial pulmonary disease due to Mycobacterium xenopi","volume":"123","author":"Costrini AM","year":"1981","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-010-9241-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.5.1365"},{"key":"e_1_2_6_8_2","first-page":"435","article-title":"The role of Mycobacterium xenopi in human disease","volume":"129","author":"Simor AE","year":"1984","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1403.061393"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.1.149"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.3.210"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.01.008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.096842"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199803000-00012"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-001-1282-1"},{"key":"e_1_2_6_16_2","first-page":"597","article-title":"Clinical features of non\u2010tuberculous mycobacterial disease: comparisons between smear\u2010positive and smear\u2010negative cases, and between Mycobacterium avium and Mycobacterium intracellulare","volume":"2","author":"Obayashi Y","year":"1998","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-489OC"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.173.1.10397099"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1843.2012.02277.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1843.2012.02277.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T16:26:47Z","timestamp":1697300807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1843.2012.02277.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,26]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1440-1843.2012.02277.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1843.2012.02277.x","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,26]]}}}